You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TAF11
Transcription initiation factor TFIID subunit 11

Protein Classes
Protein Summary
Description
Core TAFII present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively). Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit of TFIID that is present in all TFIID complexes and interacts with TBP. This subu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361288
  • ENSP00000354633
  • ENSG00000064995
  • ENST00000420584
  • ENSP00000408121

Symbol
  • TAF2I
  • TAF2I
  • PRO2134
  • TAFII28
  • MGC:15243
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.89
disease perturbation
0.79
transcription factor binding site profile
0.79
molecular function
0.7
tissue
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.01   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 233   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.01   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (23)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
HIV Infection
Reactome
HIV Life Cycle
Name
Explore in Pharos
Explore in Source
Disease
Gene expression (Transcription)
Generic Transcription Pathway
HIV Infection
HIV Life Cycle
Gene Ontology Terms (15)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (131)
1 – 10 of 131
TAF12
Tbio
Novelty: 0.06871711
p_int: 0.999999996
p_ni: 4e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
SPATA25
Tbio
Novelty: 1
p_int: 0.999999992
p_ni: 8e-9
Data Source: BioPlex
TAF7L
Tbio
Novelty: 0.04474511
p_int: 0.999999832
p_ni: 3e-9
p_wrong: 1.65e-7
Score: 0.994
Data Source: BioPlex,STRINGDB
TAF8
Tbio
Novelty: 0.00733106
p_int: 0.99999966
p_ni: 9e-8
p_wrong: 2.5e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
TBP
Tbio
Novelty: 0.00051191
Score: 0.999
Data Source: STRINGDB
TAF7
Tbio
Novelty: 0.06908096
Score: 0.999
Data Source: STRINGDB
TAF4
Tbio
Novelty: 0.03270561
Score: 0.999
Data Source: STRINGDB
TAF6
Tbio
Novelty: 0.07631444
Score: 0.999
Data Source: STRINGDB
TAF5
Tbio
Novelty: 0.0786296
Score: 0.999
Data Source: STRINGDB
TAF10
Tbio
Novelty: 0.0526107
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.01

PubMed score by year
PubTator Score  9.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: