You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
TAF11
Transcription initiation factor TFIID subunit 11

Protein Summary
Description
Core TAFII present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively). Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit of TFIID that is present in all TFIID complexes and interacts with TBP. This subu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361288
  • ENSP00000354633
  • ENSG00000064995
  • ENST00000420584
  • ENSP00000408121

Symbol
  • TAF2I
  • TAF2I
  • PRO2134
  • TAFII28
  • MGC:15243
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.89
disease perturbation
0.79
transcription factor binding site profile
0.79
molecular function
0.7
tissue
0.68


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.46   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 233   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.46   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (131)
TAF12
Tbio
Novelty:  0.04352637
p_int:  0.999999996
p_ni:  4e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
SPATA25
Tbio
Novelty:  0.80142563
p_int:  0.999999992
p_ni:  8e-9
Data Source:  BioPlex
TAF7L
Tbio
Novelty:  0.08132691
p_int:  0.999999832
p_ni:  3e-9
p_wrong:  1.65e-7
Score:  0.994
Data Source:  BioPlex,STRINGDB
TAF8
Tbio
Novelty:  0.01056638
p_int:  0.99999966
p_ni:  9e-8
p_wrong:  2.5e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
TBP
Tbio
Novelty:  0.00034941
Score:  0.999
Data Source:  STRINGDB
TAF4
Tbio
Novelty:  0.02101584
Score:  0.999
Data Source:  STRINGDB
TAF7
Tbio
Novelty:  0.05316615
Score:  0.999
Data Source:  STRINGDB
TAF6
Tbio
Novelty:  0.04357176
Score:  0.999
Data Source:  STRINGDB
TAF10
Tbio
Novelty:  0.0276004
Score:  0.999
Data Source:  STRINGDB
TAF5
Tbio
Novelty:  0.05443551
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (23)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
HIV Infection
Reactome
HIV Life Cycle
Name
Explore in Pharos
Explore in Source
Disease
Gene expression (Transcription)
Generic Transcription Pathway
HIV Infection
HIV Life Cycle
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
5
5
6
93.3
BMI-adjusted waist circumference
2
4
4
90.8
waist-hip ratio
1
3
3
88.7
red blood cell distribution width
2
2
2
88.3
BMI-adjusted waist-hip ratio
2
3
3
87.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
93.3
BMI-adjusted waist circumference
4
90.8
waist-hip ratio
3
88.7
red blood cell distribution width
2
88.3
BMI-adjusted waist-hip ratio
3
87.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TATA-box binding protein associated factor 11
VGNC:3720
462631
Macaque
TATA-box binding protein associated factor 11
718732
Mouse
MGI:1916026
68776
Rat
RGD:1305626
309638
Dog
TATA-box binding protein associated factor 11
VGNC:47074
474881
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TATA-box binding protein associated factor 11
Macaque
TATA-box binding protein associated factor 11
Mouse
Rat
Dog
TATA-box binding protein associated factor 11
Publication Statistics
PubMed Score 9.46
PubMed score by year
PubTator Score 9.90
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title