Tbio TAF13 Transcription initiation factor TFIID subunit 13

Protein Summary

Description

Component of the DNA-binding general RNA polymerase II transcription factor IID complex (TFIID). TFIID plays a critical role in the regulation of gene transcription in eukaryotic cells. Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit associated with a subset of TFIID complexes. This subunit interacts with TBP and with two other small subunits of TFIID, TAF10 and TAF11. There is a pseudogene located on chromosome 6. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q15543
• B2R5E5
• Q5TYV6

Gene Name

• TAF13

Ensembl ID

• ENST00000338366
• ENSP00000355051
• ENSG00000197780
• ENST00000461096
• ENSP00000433883

Symbol

• TAF2K
• TAFII18
• MRT60
• TAF2K
• TAFII18
• TAFII-18
• TAF(II)18

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.9
kinase perturbation	0.88
hub protein	0.82
transcription factor binding site profile	0.77
small molecule perturbation	0.7

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Initiation Factor Tfiid Subunit 13

Protein / Nucleic Acid Binding / Transcription Initiation Factor Tfiid Subunit 13

DTO Classes

Protein / Nucleic Acid Binding / Transcription Initiation Factor Tfiid Subunit 13

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.94   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 143   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.94   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0