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Tbio
TAF13
Transcription initiation factor TFIID subunit 13

Protein Summary
Description
Component of the DNA-binding general RNA polymerase II transcription factor IID complex (TFIID). TFIID plays a critical role in the regulation of gene transcription in eukaryotic cells. Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit associated with a subset of TFIID complexes. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338366
  • ENSP00000355051
  • ENSG00000197780
  • ENST00000461096
  • ENSP00000433883

Symbol
  • TAF2K
  • TAFII18
  • MRT60
  • TAF2K
  • TAFII18
  • TAFII-18
  • TAF(II)18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
kinase perturbation
0.88
hub protein
0.82
transcription factor binding site profile
0.77
small molecule perturbation
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.1   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.1   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
2
5
5
93.3
low density lipoprotein cholesterol measurement
1
4
4
89.3
alkaline phosphatase measurement
2
2
1
7.1
80.8
total cholesterol measurement
1
3
3
77.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
5
93.3
low density lipoprotein cholesterol measurement
4
89.3
alkaline phosphatase measurement
1
7.1
80.8
total cholesterol measurement
3
77.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TATA-box binding protein associated factor 13
VGNC:7002
738503
Mouse
MGI:1913500
99730
Rat
RGD:1305398
310784
Dog
TATA-box binding protein associated factor 13
VGNC:47075
100688743
Horse
TATA-box binding protein associated factor 13
VGNC:23848
100061136
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TATA-box binding protein associated factor 13
Mouse
Rat
Dog
TATA-box binding protein associated factor 13
Horse
TATA-box binding protein associated factor 13
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15543-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (27)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
HIV Infection
Reactome
HIV Life Cycle
Name
Explore in Pharos
Explore in Source
Disease
Gene expression (Transcription)
Generic Transcription Pathway
HIV Infection
HIV Life Cycle
Gene Ontology Terms (15)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (152)
1 – 10 of 152
SPATA25
Tbio
Novelty:  0.80142563
p_int:  0.999999995
p_ni:  4e-9
p_wrong:  1e-9
Data Source:  BioPlex
TAF12
Tbio
Novelty:  0.04352637
p_int:  0.999999991
p_ni:  3e-9
p_wrong:  5e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
TAF7L
Tbio
Novelty:  0.08132691
p_int:  0.999992986
p_ni:  1e-8
p_wrong:  0.000007004
Score:  0.993
Data Source:  BioPlex,STRINGDB
TAF8
Tbio
Novelty:  0.01056638
p_int:  0.999954173
p_ni:  3.9e-8
p_wrong:  0.000045787
Score:  0.999
Data Source:  BioPlex,STRINGDB
TBP
Tbio
Novelty:  0.00034941
Score:  0.999
Data Source:  STRINGDB
TAF7
Tbio
Novelty:  0.05316615
Score:  0.999
Data Source:  STRINGDB
TAF11
Tchem
Novelty:  0.10299251
Score:  0.999
Data Source:  STRINGDB
TAF10
Tbio
Novelty:  0.0276004
Score:  0.999
Data Source:  STRINGDB
TAF4
Tbio
Novelty:  0.02101584
Score:  0.998
Data Source:  STRINGDB
TAF6
Tbio
Novelty:  0.04357176
Score:  0.998
Data Source:  STRINGDB
Publication Statistics
PubMed Score  10.10

PubMed score by year
PubTator Score  7.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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