Tbio MED22 Mediator of RNA polymerase II transcription subunit 22

Protein Summary

Description

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This gene encodes a protein component of the mediator complex, which functions in the regulation of transcription by bridging interactions between gene-specific regulatory factors, RNA polymerase II, and general transcription factors. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• Q15528
• B3KW83
• B3KWX4
• O76072
• Q5T8U0

Gene Name

• MED22

Ensembl ID

• ENST00000343730
• ENSP00000342343
• ENSG00000148297
• ENST00000610672
• ENSP00000482438
• ENST00000610888
• ENSP00000478773
• ENST00000614493
• ENSP00000481493
• ENST00000626118
• ENSP00000485715
• ENSG00000281022
• ENST00000629522
• ENSP00000485880
• ENST00000629975
• ENSP00000486722
• ENST00000631196
• ENSP00000487580

Symbol

• SURF5
• SRB6
• MED24
• SURF5
• surf-5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.9
kinase perturbation	0.84
histone modification site profile	0.73
transcription factor binding site profile	0.71
virus perturbation	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.5   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 158   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.5   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0