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Tbio
SURF1
Surfeit locus protein 1

Protein Summary
Description
Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. This gene encodes a protein localized to the inner mitochondrial membrane and thought to be involved in the biogenesis of the cytochrome c oxidase complex. The protein is a member of the SURF1 family, which includes the related yeast protein SHY1 and rickettsial protein RP733. The gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity, where it shares a bidirectional promoter with SURF2 on the opposite strand. Defects in this gene are a cause of Leigh syndrome, a severe neurological disorder that is commonly associated with systemic cytochrome c oxidase deficiency. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371974
  • ENSP00000361042
  • ENSG00000148290
  • ENST00000626663
  • ENSP00000487158
  • ENSG00000280627

Symbol
  • SURF-1
  • CMT4K
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.95
histone modification site profile
0.78
biological process
0.77
molecular function
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 146.87   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 146.87   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (143)
1 – 10 of 143
IFNA5
Tbio
Novelty:  0.02838784
p_int:  0.999801713
p_ni:  0.000197778
p_wrong:  5.09e-7
Score:  0.228
Data Source:  BioPlex,STRINGDB
LPCAT2
Tbio
Family:  Enzyme
Novelty:  0.02794035
p_int:  0.996872014
p_ni:  0.003113568
p_wrong:  0.000014418
Data Source:  BioPlex
ACADVL
Tbio
Family:  Enzyme
Novelty:  0.00383705
p_int:  0.989601457
p_ni:  0.010398543
Score:  0.313
Data Source:  BioPlex,STRINGDB
COX4I1
Tbio
Family:  Enzyme
Novelty:  0.00208873
p_int:  0.955202374
p_ni:  0.008732146
p_wrong:  0.036065481
Score:  0.626
Data Source:  BioPlex,STRINGDB
CDHR2
Tbio
Novelty:  0.09806551
p_int:  0.944392396
p_ni:  0.010524294
p_wrong:  0.04508331
Data Source:  BioPlex
GBP5
Tbio
Novelty:  0.03705719
p_int:  0.913617707
p_ni:  0.085113319
p_wrong:  0.001268974
Score:  0.19
Data Source:  BioPlex,STRINGDB
EDEM2
Tbio
Family:  Enzyme
Novelty:  0.1180208
p_int:  0.913617707
p_ni:  0.085113319
p_wrong:  0.001268974
Score:  0.177
Data Source:  BioPlex,STRINGDB
COX15
Tbio
Family:  Enzyme
Novelty:  0.02252282
Score:  0.991
Data Source:  STRINGDB
CYCS
Tchem
Novelty:  0.00014004
Score:  0.981
Data Source:  STRINGDB
COX10
Tbio
Family:  Enzyme
Novelty:  0.0156235
Score:  0.956
Data Source:  STRINGDB
Pathways (11)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
RNA Polymerase II Transcription
Reactome
Respiratory electron transport
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
RNA Polymerase II Transcription
Respiratory electron transport
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
GWAS Traits (328)
Items per page:
1 – 5 of 328
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
7
10
10
8.8
99.8
alkaline phosphatase measurement
7
10
10
8.8
99.8
low density lipoprotein cholesterol measurement
13
13
36
2.9
99.8
low density lipoprotein cholesterol measurement
13
13
36
2.9
99.8
9
11
2
1.5
99.7
Items per page:
1 – 5 of 328
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
10
8.8
99.8
alkaline phosphatase measurement
10
8.8
99.8
low density lipoprotein cholesterol measurement
36
2.9
99.8
low density lipoprotein cholesterol measurement
36
2.9
99.8
2
1.5
99.7
Find similar targets by:
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
surfeit 1
722212
Mouse
MGI:98443
20930
Dog
SURF1, cytochrome c oxidase assembly factor
VGNC:46994
480681
Zebrafish
ZDB-GENE-041108-2
557970
C. elegans
175415
Species
Name
OMA
EggNOG
Inparanoid
Macaque
surfeit 1
Mouse
Dog
SURF1, cytochrome c oxidase assembly factor
Zebrafish
C. elegans
Publication Statistics
PubMed Score 146.87
PubMed score by year
PubTator Score 103.17
PubTator score by year