Protein Summary
Important for the epidermal barrier integrity. This gene encodes a protein found in corneodesmosomes, which localize to human epidermis and other cornified squamous epithelia. The encoded protein undergoes a series of cleavages during corneocyte maturation. This gene is highly polymorphic in human populations, and variation has been associated with skin diseases such as psoriasis, hypotrichosis and peeling skin syndrome. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6. [provided by RefSeq, Dec 2014]
- ENST00000259726
- ENSP00000259726
- ENSG00000137197
- ENST00000418599
- ENSP00000392863
- ENSG00000237123
- ENST00000445893
- ENSP00000388386
- ENSG00000237114
- ENST00000457875
- ENSP00000399604
- ENSG00000237165
- S
- PSS
- HTSS
- PSS1
- HTSS1
- HYPT2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.79 | ||
cellular component | 0.67 | ||
protein complex | 0.65 | ||
trait | 0.61 | ||
disease | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 131.44 (req: < 5)
Gene RIFs: 24 (req: <= 3)
Antibodies: 0 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 131.44 (req: >= 5)
Gene RIFs: 24 (req: > 3)
Antibodies: 0 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0