You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
FCN2
Ficolin-2

Protein Summary
Description
May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region. The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291744
  • ENSP00000291744
  • ENSG00000160339
  • ENST00000350339
  • ENSP00000291741

Symbol
  • FCNL
  • P35
  • FCNL
  • EBP-37
  • ficolin-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.74
protein domain
0.73
biological term
0.68
tissue
0.56
phenotype
0.52


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 224.25   (req: < 5)
Gene RIFs: 79   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 224.25   (req: >= 5)
Gene RIFs: 79   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ficolin 2
712486
Mouse
MGI:1341158
14134
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ficolin 2
Mouse
Protein Structure (13 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15485-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 13
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
Complement cascade (R-HSA-166658)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complement cascade
Reactome
Creation of C4 and C2 activators
Reactome
Ficolins bind to repetitive carbohydrate structures on the target cell surface
Reactome
Immune System
Reactome
Initial triggering of complement
Name
Explore in Pharos
Explore in Source
Complement cascade
Creation of C4 and C2 activators
Ficolins bind to repetitive carbohydrate structures on the target cell surface
Immune System
Initial triggering of complement
Gene Ontology Terms (16)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (36)
1 – 10 of 36
FCN1
Tbio
Novelty: 0.01037775
p_int: 0.999999754
p_wrong: 2.46e-7
Score: 0.938
Data Source: BioPlex,STRINGDB
MASP1
Tbio
Family: Enzyme
Novelty: 0.0029019
Score: 0.994
Data Source: Reactome,STRINGDB
MBL2
Tbio
Novelty: 0.00124156
Score: 0.994
Data Source: STRINGDB
C4B
Tbio
Novelty: 0.00068357
Score: 0.967
Data Source: STRINGDB
COLEC10
Tbio
Novelty: 0.02593638
Score: 0.967
Data Source: STRINGDB
C4A
Tbio
Novelty: 0.00062793
Score: 0.966
Data Source: STRINGDB
MASP2
Tbio
Family: Enzyme
Novelty: 0.00466852
Score: 0.951
Data Source: Reactome,STRINGDB
C2
Tbio
Novelty: 0.00974862
Score: 0.946
Data Source: STRINGDB
COLEC11
Tbio
Novelty: 0.02989413
Score: 0.939
Data Source: STRINGDB
FCN3
Tbio
Novelty: 0.00771958
Score: 0.911
Data Source: STRINGDB
Publication Statistics
PubMed Score  224.25

PubMed score by year
PubTator Score  130.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer