Tbio SKIV2L Helicase SKI2W

Protein Summary

Description

Helicase; has ATPase activity. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C). DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a human homologue of yeast SKI2 and may be involved in antiviral activity by blocking translation of poly(A) deficient mRNAs. This gene is located in the class III region of the major histocompatibility complex. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q15477
• O15005
• Q12902
• Q15476
• Q5ST66
• Ski2

Gene Name

• SKIV2L

Ensembl ID

• ENST00000375394
• ENSP00000364543
• ENSG00000204351
• ENST00000383336
• ENSP00000372827
• ENSG00000206353
• ENST00000412823
• ENSP00000400626
• ENSG00000232616
• ENST00000421789
• ENSP00000399530
• ENSG00000228896
• ENST00000429465
• ENSP00000412310
• ENSG00000223493
• ENST00000448219
• ENSP00000394400
• ENSG00000225737

Symbol

• DDX13
• SKI2W
• SKIV2
• W
• HLP
• 170A
• SKI2
• DDX13
• SKI2W
• SKIV2
• THES2
• SKIV2L1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
disease perturbation	0.95
protein domain	0.92
hub protein	0.82
cell line	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.75   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 83   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.75   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0