You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
SHH
Sonic hedgehog protein

Protein Summary
Description
Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). Sonic hedgehog protein N-product: The dually lipidated sonic hedgehog protein N-product (ShhNp) is a morphogen which is essential for a variety of patterning events during development. Induces ventral cell fate in the neural tube and somites (PubMed:24863049). Involved in the patterning of the anterior-posterior axis of the developing limb bud (By similarity). Essential for axon guidance (By similarity). Binds to the patched (PTCH1) receptor, which functions in a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297261
  • ENSP00000297261
  • ENSG00000164690

Symbol
  • TPT
  • HHG1
  • HLP3
  • HPE3
  • SMMCI
  • ShhNC
  • TPTPS
  • MCOPCB5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
protein domain
0.97
phenotype
0.75
molecular function
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4551.7   (req: < 5)
Gene RIFs: 424   (req: <= 3)
Antibodies: 529   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4551.7   (req: >= 5)
Gene RIFs: 424   (req: > 3)
Antibodies: 529   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 147
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1