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Tbio
SHB
SH2 domain-containing adapter protein B

Protein Summary
Description
Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377707
  • ENSP00000366936
  • ENSG00000107338

Symbol
  • bA3J10.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.86
trait
0.75
interacting protein
0.73
transcription factor perturbation
0.68
microRNA
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 321.24   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 266   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 321.24   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
82.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
82.1
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SH2 domain containing adaptor protein B
VGNC:10058
465107
Macaque
SH2 domain containing adaptor protein B
716169
Mouse
MGI:98294
230126
Rat
RGD:1565350
362513
Dog
SH2 domain containing adaptor protein B
VGNC:46138
481619
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SH2 domain containing adaptor protein B
Macaque
SH2 domain containing adaptor protein B
Mouse
Rat
Dog
SH2 domain containing adaptor protein B
Pathways (16)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by Receptor Tyrosine Kinases
Reactome
Signaling by VEGF
Reactome
VEGFA-VEGFR2 Pathway
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by Receptor Tyrosine Kinases
Signaling by VEGF
VEGFA-VEGFR2 Pathway
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
CAFA
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (67)
1 – 10 of 67
FBLIM1
Tbio
Novelty: 0.0332985
p_int: 0.999999449
p_ni: 3.2e-8
p_wrong: 5.19e-7
Data Source: BioPlex
NCK2
Tbio
Novelty: 0.02220251
p_int: 0.999999271
p_ni: 2.26e-7
p_wrong: 5.03e-7
Score: 0.311
Data Source: BioPlex,STRINGDB
WDYHV1
Tbio
Family: Enzyme
Novelty: 0.1844203
p_int: 0.99999079
p_ni: 6.8e-8
p_wrong: 0.000009142
Score: 0.189
Data Source: BioPlex,STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
Score: 0.978
Data Source: Reactome,STRINGDB
CRK
Tbio
Novelty: 0.00238512
Score: 0.974
Data Source: Reactome,STRINGDB
KDR
Tclin
Family: Kinase
Novelty: 0.00016219
Score: 0.959
Data Source: Reactome,STRINGDB
VAV1
Tchem
Novelty: 0.00180518
Score: 0.945
Data Source: STRINGDB
PDGFRA
Tclin
Family: Kinase
Novelty: 0.00066909
Score: 0.944
Data Source: STRINGDB
VEGFA
Tclin
Novelty: 0.0000378
Score: 0.931
Data Source: Reactome,STRINGDB
PTK2
Tclin
Family: Kinase
Novelty: 0.00066622
Score: 0.926
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  321.24

PubMed score by year
PubTator Score  72.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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