Protein Summary
Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity. The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membr ...more
- ENST00000361101
- ENSP00000354398
- ENSG00000108669
- ENST00000446868
- ENSP00000389095
- ENST00000585509
- ENSP00000465940
- ENST00000589297
- ENSP00000466512
- ENST00000591455
- ENSP00000465665
- D17S811E
- PSCD1
- B2-1
- SEC7
- PSCD1
- D17S811E
- CYTOHESIN-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
hub protein | 0.92 | ||
transcription factor | 0.77 | ||
cellular component | 0.73 | ||
transcription factor binding site profile | 0.72 | ||
tissue | 0.69 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 167.9 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 236 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 167.9 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 236 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (101)
IPCEF1
Novelty: 0.3372832
p_int: 0.999999998
p_ni: 2e-9
Score: 0.457
Data Source: BioPlex,STRINGDB
CYTIP
Novelty: 0.01965202
p_int: 0.999999995
p_ni: 5e-9
Score: 0.884
Data Source: BioPlex,STRINGDB
CNKSR1
Family: Enzyme
Novelty: 0.06710697
p_int: 0.999999976
p_ni: 5e-9
p_wrong: 1.9e-8
Score: 0.346
Data Source: BioPlex,STRINGDB
CCDC120
Novelty: 0.48574876
p_int: 0.999999678
p_ni: 3.22e-7
Score: 0.225
Data Source: BioPlex,STRINGDB
INAVA
Novelty: 0.19311978
p_int: 0.999996585
p_ni: 0.000003415
Score: 0.392
Data Source: BioPlex,STRINGDB
CCDC40
Novelty: 0.06726469
p_int: 0.978007647
p_ni: 0.019410315
p_wrong: 0.002582038
Data Source: BioPlex
Nearest Tclin Targets
Pathways (8)
Reactome (4)
KEGG (2)
PathwayCommons (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Intra-Golgi and retrograde Golgi-to-ER traffic | ||||
Reactome | Intra-Golgi traffic | ||||
Reactome | Membrane Trafficking | ||||
Reactome | Vesicle-mediated transport | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Intra-Golgi and retrograde Golgi-to-ER traffic | ||||
Intra-Golgi traffic | ||||
Membrane Trafficking | ||||
Vesicle-mediated transport | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (2)
Components (7)
Processes (4)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
2 | 2 | 2 | 76.7 | ||||||
heel bone mineral density | 2 | 2 | 2 | 61.8 | |||||
red blood cell distribution width | 1 | 1 | 1 | 42.3 | |||||
HbA1c measurement | 1 | 1 | 1 | 42.3 | |||||
high density lipoprotein cholesterol measurement | 1 | 1 | 1 | 21.5 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
2 | 76.7 | ||||||
heel bone mineral density | 2 | 61.8 | |||||
red blood cell distribution width | 1 | 42.3 | |||||
HbA1c measurement | 1 | 42.3 | |||||
high density lipoprotein cholesterol measurement | 1 | 21.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | cytohesin 1 | VGNC:51646 | 454926 | |||||
Macaque | cytohesin 1 | 710305 | ||||||
Mouse | MGI:1334257 | 19157 | ||||||
Rat | RGD:620397 | 116691 | ||||||
Dog | cytohesin 1 | VGNC:49091 | 608079 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | cytohesin 1 | |||||
Macaque | cytohesin 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | cytohesin 1 | |||||
Publication Statistics
PubMed Score 167.90
PubMed score by year
PubTator Score 161.35
PubTator score by year
Related Publications
Text Mined References (38)
GeneRif Annotations (10)
Items per page:
0 of 0
PMID | Year | Title |
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