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Tbio
CYTH1
Cytohesin-1

Protein Summary
Description
Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity. The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361101
  • ENSP00000354398
  • ENSG00000108669
  • ENST00000446868
  • ENSP00000389095
  • ENST00000585509
  • ENSP00000465940
  • ENST00000589297
  • ENSP00000466512
  • ENST00000591455
  • ENSP00000465665

Symbol
  • D17S811E
  • PSCD1
  • B2-1
  • SEC7
  • PSCD1
  • D17S811E
  • CYTOHESIN-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.92
transcription factor
0.77
cellular component
0.73
transcription factor binding site profile
0.72
tissue
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.9   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 236   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.9   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 236   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (101)
IPCEF1
Tbio
Novelty:  0.3372832
p_int:  0.999999998
p_ni:  2e-9
Score:  0.457
Data Source:  BioPlex,STRINGDB
CYTIP
Tbio
Novelty:  0.01965202
p_int:  0.999999995
p_ni:  5e-9
Score:  0.884
Data Source:  BioPlex,STRINGDB
CNKSR1
Tchem
Family:  Enzyme
Novelty:  0.06710697
p_int:  0.999999976
p_ni:  5e-9
p_wrong:  1.9e-8
Score:  0.346
Data Source:  BioPlex,STRINGDB
CCDC120
Tbio
Novelty:  0.48574876
p_int:  0.999999678
p_ni:  3.22e-7
Score:  0.225
Data Source:  BioPlex,STRINGDB
INAVA
Tbio
Novelty:  0.19311978
p_int:  0.999996585
p_ni:  0.000003415
Score:  0.392
Data Source:  BioPlex,STRINGDB
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.999800512
p_ni:  0.000199487
Data Source:  BioPlex
CCDC40
Tbio
Novelty:  0.06726469
p_int:  0.978007647
p_ni:  0.019410315
p_wrong:  0.002582038
Data Source:  BioPlex
ARF1
Tchem
Family:  Enzyme
Novelty:  0.00208554
Score:  0.996
Data Source:  Reactome,STRINGDB
ARF6
Tbio
Family:  Enzyme
Novelty:  0.00278138
Score:  0.957
Data Source:  STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.935
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Intra-Golgi traffic
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic
Intra-Golgi traffic
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
2
76.7
heel bone mineral density
2
2
2
61.8
red blood cell distribution width
1
1
1
42.3
HbA1c measurement
1
1
1
42.3
high density lipoprotein cholesterol measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
76.7
heel bone mineral density
2
61.8
red blood cell distribution width
1
42.3
HbA1c measurement
1
42.3
high density lipoprotein cholesterol measurement
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytohesin 1
VGNC:51646
454926
Macaque
cytohesin 1
710305
Mouse
MGI:1334257
19157
Rat
RGD:620397
116691
Dog
cytohesin 1
VGNC:49091
608079
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytohesin 1
Macaque
cytohesin 1
Mouse
Rat
Dog
cytohesin 1
Publication Statistics
PubMed Score 167.90
PubMed score by year
PubTator Score 161.35
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title