Tbio CYTH1 Cytohesin-1

Protein Summary

Description

Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity. The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Uniprot Accession IDs

• Q15438
• A6NFW7
• B7Z1T4
• Q9P123
• Q9P124

Gene Name

• CYTH1

Ensembl ID

• ENST00000361101
• ENSP00000354398
• ENSG00000108669
• ENST00000446868
• ENSP00000389095
• ENST00000585509
• ENSP00000465940
• ENST00000589297
• ENSP00000466512
• ENST00000591455
• ENSP00000465665

Symbol

• D17S811E
• PSCD1
• B2-1
• SEC7
• PSCD1
• D17S811E
• CYTOHESIN-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.92
transcription factor	0.77
cellular component	0.73
transcription factor binding site profile	0.72
tissue	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.9   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 236   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.9   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 236   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (101)

Explore Interacting Targets

1 – 10 of 101

• See Interactions on String-DB

IPCEF1

Tbio

Novelty:  0.3372832

p_int:  0.999999998

p_ni:  2e-9

Score:  0.457

Data Source:  BioPlex,STRINGDB

CYTIP

Tbio

Novelty:  0.01965202

p_int:  0.999999995

p_ni:  5e-9

Score:  0.884

Data Source:  BioPlex,STRINGDB

CNKSR1

Tchem

Family:  Enzyme

Novelty:  0.06710697

p_int:  0.999999976

p_ni:  5e-9

p_wrong:  1.9e-8

Score:  0.346

Data Source:  BioPlex,STRINGDB

CCDC120

Tbio

Novelty:  0.48574876

p_int:  0.999999678

p_ni:  3.22e-7

Score:  0.225

Data Source:  BioPlex,STRINGDB

INAVA

Tbio

Novelty:  0.19311978

p_int:  0.999996585

p_ni:  0.000003415

Score:  0.392

Data Source:  BioPlex,STRINGDB

SYCE1

Tbio

Novelty:  0.05038876

p_int:  0.999800512

p_ni:  0.000199487

Data Source:  BioPlex

CCDC40

Tbio

Novelty:  0.06726469

p_int:  0.978007647

p_ni:  0.019410315

p_wrong:  0.002582038

Data Source:  BioPlex

ARF1

Tchem

Family:  Enzyme

Novelty:  0.00208554

Score:  0.996

Data Source:  Reactome,STRINGDB

ARF6

Tbio

Family:  Enzyme

Novelty:  0.00278138

Score:  0.957

Data Source:  STRINGDB

RHOA

Tbio

Family:  Enzyme

Novelty:  0.00022204

Score:  0.935

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (8)

Reactome (4)

KEGG (2)

PathwayCommons (2)

Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Intra-Golgi and retrograde Golgi-to-ER traffic	187 targets	R-HSA-6811442
Reactome	Intra-Golgi traffic	45 targets	R-HSA-6811438
Reactome	Membrane Trafficking	612 targets	R-HSA-199991
Reactome	Vesicle-mediated transport	725 targets	R-HSA-5653656

Name	Explore in Pharos	Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic	187 targets	R-HSA-6811442
Intra-Golgi traffic	45 targets	R-HSA-6811438
Membrane Trafficking	612 targets	R-HSA-199991
Vesicle-mediated transport	725 targets	R-HSA-5653656

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (13)

Functions (2)

Components (7)

Processes (4)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
ARF guanyl-nucleotide exchange factor activity	Inferred from Direct Assay (IDA)	UniProtKB
lipid binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (9)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
type II diabetes mellitus	EFO_0001360	2	2	2		76.7
heel bone mineral density	EFO_0009270	2	2	2		61.8
red blood cell distribution width	EFO_0005192	1	1	1		42.3
HbA1c measurement	EFO_0004541	1	1	1		42.3
high density lipoprotein cholesterol measurement	EFO_0004612	1	1	1		21.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
type II diabetes mellitus	EFO_0001360	2		76.7
heel bone mineral density	EFO_0009270	2		61.8
red blood cell distribution width	EFO_0005192	1		42.3
HbA1c measurement	EFO_0004541	1		42.3
high density lipoprotein cholesterol measurement	EFO_0004612	1		21.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Cell junction
Cell membrane
Coiled coil
Complete proteome
Cytoplasm
Guanine-nucleotide releasing factor
Lipid-binding

GWAS Trait Find Similar Targets

No Header	No Header
atrial fibrillation
gut microbiome measurement
HbA1c measurement
heel bone mineral density
high density lipoprotein cholesterol measurement
red blood cell distribution width
systolic blood pressure
type II diabetes mellitus
ulcerative colitis

MGI Phenotype Find Similar Targets

No Header	No Header
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	cytohesin 1	VGNC:51646	454926
Macaque	cytohesin 1		710305
Mouse	cytohesin 1	MGI:1334257	19157
Rat	cytohesin 1	RGD:620397	116691
Dog	cytohesin 1	VGNC:49091	608079

Species	Name	OMA	EggNOG	Inparanoid
Chimp	cytohesin 1
Macaque	cytohesin 1
Mouse	cytohesin 1
Rat	cytohesin 1
Dog	cytohesin 1

Publication Statistics

PubMed Score 167.90

PubMed score by year

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PubTator Score 161.35

PubTator score by year

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Related Publications

Text Mined References (38)

GeneRif Annotations (10)

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10

0 of 0

PMID	Year	Title