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Tbio
SEC23B
Protein transport protein Sec23B

Protein Summary
Description
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The function of this gene product has been implicated in cargo selection and concentration. Multiple alternatively spliced transcript variants have been identified in this gene. [provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262544
  • ENSP00000262544
  • ENSG00000101310
  • ENST00000336714
  • ENSP00000338844
  • ENST00000377465
  • ENSP00000366685
  • ENST00000377475
  • ENSP00000366695
  • ENST00000650089
  • ENSP00000497473

Symbol
  • CWS7
  • CDAII
  • CDAN2
  • CDA-II
  • HEMPAS
  • hSec23B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
0.99
disease perturbation
0.96
protein domain
0.92
transcription factor perturbation
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.34   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 158   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.34   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (162)
1 – 10 of 162
SEC24D
Tbio
Novelty:  0.04795527
p_int:  0.999999442
p_ni:  5.58e-7
Score:  0.989
Data Source:  BioPlex,STRINGDB
BTBD6
Tdark
Novelty:  0.24005804
p_int:  0.999992792
p_ni:  0.00000174
p_wrong:  0.000005468
Data Source:  BioPlex
SEC23IP
Tbio
Novelty:  0.0925721
p_int:  0.999945792
p_ni:  0.000054208
Score:  0.478
Data Source:  BioPlex,STRINGDB
SEC24B
Tbio
Novelty:  0.01031644
p_int:  0.999800348
p_ni:  0.000199652
Score:  0.992
Data Source:  BioPlex,STRINGDB
PLEKHA3
Tbio
Novelty:  0.06598909
p_int:  0.999374023
p_ni:  0.000613373
p_wrong:  0.000012604
Data Source:  BioPlex
SEC24A
Tbio
Novelty:  0.07724534
p_int:  0.998479007
p_ni:  0.001520993
Score:  0.993
Data Source:  BioPlex,STRINGDB
SEC24C
Tbio
Novelty:  0.05842956
p_int:  0.996264106
p_ni:  0.003735895
Score:  0.992
Data Source:  BioPlex,STRINGDB
SEC16A
Tbio
Novelty:  0.02221416
p_int:  0.994898315
p_ni:  0.005101685
Score:  0.845
Data Source:  BioPlex,STRINGDB
FAM83H
Tbio
Novelty:  0.02527211
p_int:  0.988693868
p_ni:  0.011306127
p_wrong:  5e-9
Data Source:  BioPlex
EIF4A3
Tchem
Novelty:  0.00981496
p_int:  0.929131348
p_ni:  0.070868652
Data Source:  BioPlex
Pathways (15)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Protein processing in endoplasmic reticulum
Name
Explore in Pharos
Explore in Source
Protein processing in endoplasmic reticulum
Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
1
1
49.5
hemoglobin measurement
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
49.5
hemoglobin measurement
1
44.2
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Sec23 homolog B, coat complex II component
VGNC:9974
458432
Macaque
Sec23 homolog B, coat complex II component
698440
Mouse
MGI:1350925
27054
Dog
Sec23 homolog B, coat complex II component
VGNC:45970
477142
Horse
Sec23 homolog B, coat complex II component
VGNC:22790
100050440
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Sec23 homolog B, coat complex II component
Macaque
Sec23 homolog B, coat complex II component
Mouse
Dog
Sec23 homolog B, coat complex II component
Horse
Sec23 homolog B, coat complex II component
Publication Statistics
PubMed Score 52.34
PubMed score by year
PubTator Score 86.90
PubTator score by year