Tbio SEC23B Protein transport protein Sec23B

Protein Summary

Description

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The function of this gene product has been implicated in cargo selection and concentration. Multiple alternatively spliced transcript variants have been identified in this gene. [provided by RefSeq, Feb 2010]

Uniprot Accession IDs

• Q15437
• D3DW33
• Q503A9
• Q5W183
• Q9BS15
• Q9BSI2
• Q9H1D7
• hSec23B

Gene Name

• SEC23B

Ensembl ID

• ENST00000262544
• ENSP00000262544
• ENSG00000101310
• ENST00000336714
• ENSP00000338844
• ENST00000377465
• ENSP00000366685
• ENST00000377475
• ENSP00000366695
• ENST00000650089
• ENSP00000497473

Symbol

• CWS7
• CDAII
• CDAN2
• CDA-II
• HEMPAS
• hSec23B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
kinase perturbation	0.99
disease perturbation	0.96
protein domain	0.92
transcription factor perturbation	0.91

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Protein Transport Protein Sec23b

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Protein Transport Protein Sec23b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.09   (req: < 5)

Gene RIFs: 33   (req: <= 3)

Antibodies: 158   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.09   (req: >= 5)

Gene RIFs: 33   (req: > 3)

Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0