Tbio SEC23A Protein transport protein Sec23A

Protein Summary

Description

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Required for the translocation of insulin-induced glucose transporter SLC2A4/GLUT4 to the cell membrane (By similarity). The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q15436
• B2R5P4
• B3KXI2
• Q8NE16
• hSec23A

Gene Name

• SEC23A

Ensembl ID

• ENST00000307712
• ENSP00000306881
• ENSG00000100934
• ENST00000537403
• ENSP00000444193

Symbol

• CLSD
• hSec23A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
protein domain	0.92
transcription factor perturbation	0.84
histone modification site profile	0.82
pathway	0.76

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Protein Transport Protein Sec23a

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Protein Transport Protein Sec23a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.63   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 146   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.63   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0