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Tbio
PPP1R7
Protein phosphatase 1 regulatory subunit 7

Protein Summary
Description
Regulatory subunit of protein phosphatase 1. This gene encodes a protein subunit that regulates the activity of the serine/threonine phosphatase, protein phosphatase-1. The encoded protein is required for completion of the mitotic cycle and for targeting protein phosphatase-1 to mitotic kinetochores. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234038
  • ENSP00000234038
  • ENSG00000115685
  • ENST00000272983
  • ENSP00000272983
  • ENST00000401987
  • ENSP00000385466
  • ENST00000402734
  • ENSP00000385012
  • ENST00000406106
  • ENSP00000385022
  • ENST00000407025
  • ENSP00000385657

Symbol
  • SDS22
  • SDS22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.98
disease perturbation
0.96
transcription factor perturbation
0.91
histone modification site profile
0.87
transcription factor binding site profile
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.11   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 227   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.11   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
p_int:  0.999987237
p_ni:  0.000012763
Score:  0.998
Data Source:  BioPlex,STRINGDB
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
p_int:  0.999982089
p_ni:  0.000017911
Score:  0.961
Data Source:  BioPlex,STRINGDB
SH2D4A
Tbio
Novelty:  0.12343277
p_int:  0.996487611
p_ni:  0.003512389
Score:  0.869
Data Source:  BioPlex,STRINGDB
CCDC181
Tdark
Novelty:  0.52897379
p_int:  0.990353967
p_ni:  0.009646034
Data Source:  BioPlex
UBXN2A
Tbio
Novelty:  0.52282698
p_int:  0.963412572
p_ni:  0.036587428
Score:  0.409
Data Source:  BioPlex,STRINGDB
MAGEB3
Tdark
Novelty:  0.22157143
p_int:  0.95844275
p_ni:  0.04155725
Score:  0.519
Data Source:  BioPlex,STRINGDB
PRICKLE3
Tbio
Novelty:  0.26347141
p_int:  0.944827668
p_ni:  0.055172332
Score:  0.171
Data Source:  BioPlex,STRINGDB
UBXN2B
Tbio
Novelty:  0.67291382
p_int:  0.939263991
p_ni:  0.060736009
Score:  0.409
Data Source:  BioPlex,STRINGDB
PPP1R16B
Tbio
Family:  Enzyme
Novelty:  0.08773047
p_int:  0.930743866
p_ni:  0.069256134
Score:  0.845
Data Source:  BioPlex,STRINGDB
PPP1R13B
Tbio
Novelty:  0.03903985
p_int:  0.894895797
p_ni:  0.105104203
Score:  0.19
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
75.9
mean reticulocyte volume
1
1
1
65.3
BMI-adjusted hip circumference
2
3
3
62
IGF-1 measurement
1
1
1
44.2
alkaline phosphatase measurement
1
1
0
6.3
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
75.9
mean reticulocyte volume
1
65.3
BMI-adjusted hip circumference
3
62
IGF-1 measurement
1
44.2
alkaline phosphatase measurement
0
6.3
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory subunit 7
VGNC:14345
460079
Macaque
protein phosphatase 1 regulatory subunit 7
700574
Mouse
MGI:1913635
66385
Dog
protein phosphatase 1 regulatory subunit 7
100855698
Horse
protein phosphatase 1 regulatory subunit 7
VGNC:52421
100067637
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory subunit 7
Macaque
protein phosphatase 1 regulatory subunit 7
Mouse
Dog
protein phosphatase 1 regulatory subunit 7
Horse
protein phosphatase 1 regulatory subunit 7
Publication Statistics
PubMed Score 54.11
PubMed score by year
PubTator Score 18.36
PubTator score by year
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Related Publications
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PMID
Year
Title