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Tbio
RBMS2
RNA-binding motif, single-stranded-interacting protein 2

Protein Summary
Description
The protein encoded by this gene is a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. The RBMS proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. This protein was isolated by phenotypic complementation of cdc2 and cdc13 mutants of yeast and is thought to suppress cdc2 and cdc13 mutants through the induction of translation of cdc2. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262031
  • ENSP00000262031
  • ENSG00000076067

Symbol
  • SCR3
  • SCR3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
virus perturbation
0.97
disease perturbation
0.93
transcription factor perturbation
0.91
microRNA
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.36   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 196   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.36   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 196   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
1
1
55.7
amino acid measurement
1
1
1
44.7
hemoglobin measurement
1
1
1
40.5
platelet count
1
1
1
13.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
55.7
amino acid measurement
1
44.7
hemoglobin measurement
1
40.5
platelet count
1
13.9
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA binding motif single stranded interacting protein 2
VGNC:10080
467094
Macaque
RNA binding motif single stranded interacting protein 2
713163
Mouse
MGI:1861776
56516
Rat
RGD:1304813
288771
Dog
RNA binding motif single stranded interacting protein 2
VGNC:45428
481115
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA binding motif single stranded interacting protein 2
Macaque
RNA binding motif single stranded interacting protein 2
Mouse
Rat
Dog
RNA binding motif single stranded interacting protein 2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (9)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (45)
1 – 10 of 45
ELAVL2
Tbio
Novelty: 0.00370708
p_int: 0.999127689
p_ni: 0.000041644
p_wrong: 0.000830667
Score: 0.2
Data Source: BioPlex,STRINGDB
RBFOX2
Tbio
Novelty: 0.00856339
p_int: 0.923941308
p_ni: 0.000138979
p_wrong: 0.075919713
Score: 0.204
Data Source: BioPlex,STRINGDB
TRA2B
Tbio
Novelty: 0.0146833
Score: 0.841
Data Source: STRINGDB
EIF4H
Tchem
Novelty: 0.03604365
Score: 0.818
Data Source: STRINGDB
SRSF3
Tbio
Novelty: 0.01015895
Score: 0.723
Data Source: STRINGDB
CD55
Tbio
Novelty: 0.0005689
Score: 0.659
Data Source: STRINGDB
CFHR3
Tbio
Novelty: 0.01779009
Score: 0.63
Data Source: STRINGDB
SHLD1
Tbio
Novelty: 1.03046307
Score: 0.586
Data Source: STRINGDB
CFHR2
Tbio
Novelty: 0.05323507
Score: 0.559
Data Source: STRINGDB
CFHR1
Tbio
Novelty: 0.00676665
Score: 0.559
Data Source: STRINGDB
Publication Statistics
PubMed Score  37.36

PubMed score by year
PubTator Score  21.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer