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Tbio
SAFB
Scaffold attachment factor B1

Protein Summary
Description
Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (By similarity). Can function as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription. When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). Can inhibit cell proliferation. This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292123
  • ENSP00000292123
  • ENSG00000160633
  • ENST00000454510
  • ENSP00000415895
  • ENST00000588852
  • ENSP00000467423
  • ENST00000592224
  • ENSP00000464840

Symbol
  • HAP
  • HET
  • SAFB1
  • HAP
  • HET
  • SAF-B
  • SAFB1
  • SAB-B1
  • SAF-B1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.96
ligand (protein) perturbation
0.96
disease perturbation
0.79
histone modification site profile
0.73
kinase perturbation
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.18   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 283   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.18   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 283   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
24
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
24
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
scaffold attachment factor B
VGNC:2258
455619
Macaque
scaffold attachment factor B
696356
Mouse
MGI:2146974
224903
Rat
RGD:620613
64196
Dog
scaffold attachment factor B
VGNC:45844
485028
Species
Name
OMA
EggNOG
Inparanoid
Chimp
scaffold attachment factor B
Macaque
scaffold attachment factor B
Mouse
Rat
Dog
scaffold attachment factor B
Pathways (471)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
SUMO E3 ligases SUMOylate target proteins
Reactome
SUMOylation
Reactome
SUMOylation of transcription cofactors
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
SUMO E3 ligases SUMOylate target proteins
SUMOylation
SUMOylation of transcription cofactors
Gene Ontology Terms (14)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (133)
1 – 10 of 133
FURIN
Tchem
Family: Enzyme
Novelty: 0.00055079
p_int: 0.995516788
p_ni: 0.004483207
p_wrong: 5e-9
Data Source: BioPlex
ELAVL2
Tbio
Novelty: 0.00370708
p_int: 0.952308756
p_ni: 0.047691244
Score: 0.199
Data Source: BioPlex,STRINGDB
CAPN13
Tdark
Novelty: 0.27206398
p_int: 0.825093247
p_ni: 0.174906753
Score: 0.199
Data Source: BioPlex,STRINGDB
APOBEC3D
Tbio
Novelty: 0.01102619
p_int: 0.805820743
p_ni: 0.194179257
Score: 0.539
Data Source: BioPlex,STRINGDB
ESR1
Tclin
Family: NR
Novelty: 0.00005938
Score: 0.959
Data Source: STRINGDB
PIAS1
Tbio
Family: TF
Novelty: 0.00987743
Score: 0.941
Data Source: STRINGDB
SUMO1
Tbio
Novelty: 0.00137629
Score: 0.934
Data Source: Reactome,STRINGDB
MATR3
Tbio
Novelty: 0.01218438
Score: 0.927
Data Source: STRINGDB
SUMO2
Tbio
Novelty: 0.00366833
Score: 0.922
Data Source: Reactome,STRINGDB
HNRNPA1
Tchem
Novelty: 0.0020871
Score: 0.918
Data Source: STRINGDB
Publication Statistics
PubMed Score  66.18

PubMed score by year
PubTator Score  51.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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