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Tchem
RPS6KA1
Ribosomal protein S6 kinase alpha-1

Protein Summary
Description
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374168
  • ENSP00000363283
  • ENSG00000117676
  • ENST00000526792
  • ENSP00000431651
  • ENST00000530003
  • ENSP00000432281
  • ENST00000531382
  • ENSP00000435412
  • ENST00000628081
  • ENSP00000487553
  • ENSG00000281877
  • ENST00000628256
  • ENSP00000487349
  • ENST00000629832
  • ENSP00000486881
  • ENST00000631108
  • ENSP00000487166

Symbol
  • MAPKAPK1A
  • RSK1
  • RSK
  • HU-1
  • RSK1
  • p90Rsk
  • MAPKAPK1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
drug perturbation
0.99
interacting protein
0.99
virus perturbation
0.99
kinase perturbation
0.97


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 499.8   (req: < 5)
Gene RIFs: 73   (req: <= 3)
Antibodies: 1508   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 499.8   (req: >= 5)
Gene RIFs: 73   (req: > 3)
Antibodies: 1508   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 25
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (25)
1 – 10 of 25
staurosporine
Rendered image for staurosporine
lestaurtinib
Rendered image for lestaurtinib
CHEMBL4465866
Rendered image for CHEMBL4465866
CHEMBL3975634
Rendered image for CHEMBL3975634
GSK-1838705A
Rendered image for GSK-1838705A
dorsomorphin
Rendered image for dorsomorphin
compound 33 [PMID: 19364658]
Rendered image for compound 33 [PMID: 19364658]
BI-D1870
Rendered image for BI-D1870
CHEMBL4062453
Rendered image for CHEMBL4062453
prexasertib
Rendered image for prexasertib
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
81.1
lymphocyte count
2
2
2
79.4
mean corpuscular hemoglobin concentration
1
1
1
71.5
forced expiratory volume
1
2
2
66.6
mean reticulocyte volume
1
1
1
64.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
81.1
lymphocyte count
2
79.4
mean corpuscular hemoglobin concentration
1
71.5
forced expiratory volume
2
66.6
mean reticulocyte volume
1
64.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S6 kinase A1
VGNC:11015
456664
Macaque
ribosomal protein S6 kinase A1
714794
Mouse
MGI:104558
20111
Rat
RGD:620675
81771
Dog
ribosomal protein S6 kinase A1
VGNC:45738
487353
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S6 kinase A1
Macaque
ribosomal protein S6 kinase A1
Mouse
Rat
Dog
ribosomal protein S6 kinase A1
Protein Structure (17 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15418-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 17
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (93)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 49
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Axon guidance
Reactome
CREB phosphorylation
Reactome
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Reactome
Cellular Senescence
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Axon guidance
CREB phosphorylation
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Cellular Senescence
Gene Ontology Terms (22)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (163)
1 – 10 of 163
MISP
Tbio
Novelty:  0.02030151
p_int:  0.999998591
p_ni:  0.000001408
Score:  0.189
Data Source:  BioPlex,STRINGDB
FYN
Tclin
Family:  Kinase
Novelty:  0.00072167
p_int:  0.999995634
p_ni:  0.000004366
Score:  0.3
Data Source:  BioPlex,STRINGDB
CTTN
Tbio
Novelty:  0.0017962
p_int:  0.999936605
p_ni:  0.000063395
Score:  0.16
Data Source:  BioPlex,STRINGDB
IRGC
Tbio
Family:  Enzyme
Novelty:  0.10743948
p_int:  0.999912714
p_ni:  0.000087056
p_wrong:  2.3e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
CSNK2B
Tbio
Family:  Kinase
Novelty:  0.00152367
p_int:  0.999705319
p_ni:  0.000294681
Score:  0.349
Data Source:  BioPlex,STRINGDB
IL17RA
Tclin
Novelty:  0.00416706
p_int:  0.999671837
p_ni:  0.000314338
p_wrong:  0.000013825
Score:  0.169
Data Source:  BioPlex,STRINGDB
FGFR2
Tclin
Family:  Kinase
Novelty:  0.00066613
p_int:  0.999312808
p_ni:  0.000687183
p_wrong:  9e-9
Score:  0.234
Data Source:  BioPlex,STRINGDB
PAPOLG
Tbio
Family:  Enzyme
Novelty:  0.02468251
p_int:  0.998218185
p_ni:  0.001781815
Data Source:  BioPlex
FAM136A
Tdark
Novelty:  0.4050275
p_int:  0.996178284
p_ni:  0.003585191
p_wrong:  0.000236525
Data Source:  BioPlex
RAB27A
Tchem
Family:  Enzyme
Novelty:  0.00369416
p_int:  0.989674122
p_ni:  0.010325877
Data Source:  BioPlex
Publication Statistics
PubMed Score  499.80

PubMed score by year
PubTator Score  164.39

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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