Protein Classes
Protein Summary
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. This gene encodes a protein with a markedly acidic C terminus; the basic N-terminus is highly homologous to the N-terminus of a related gene, CNN1. Members of the CNN gene family all contain similar tandemly repeated motifs. This encoded protein is associated with the cytoskeleton but is not involved in contraction. [provided by RefSeq, Jul 2008]
- ENST00000370206
- ENSP00000359225
- ENSG00000117519
- ENST00000394202
- ENSP00000377752
- ENST00000545882
- ENSP00000440081
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.99 | ||
PubMedID | 0.89 | ||
disease perturbation | 0.83 | ||
transcription factor binding site profile | 0.77 | ||
interacting protein | 0.73 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.62 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 205 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.62 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 205 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Gene Ontology Terms (14)
Functions (4)
Components (7)
Processes (3)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (51)
1 – 10 of 51
CNN2
Novelty: 0.06148819
p_int: 1
Score: 0.529
Data Source: BioPlex,STRINGDB
CARM1
Family: Epigenetic
Novelty: 0.0078817
p_int: 0.851472364
p_ni: 0.148527636
Score: 0.261
Data Source: BioPlex,STRINGDB
CALD1
Novelty: 0.00107425
Score: 0.754
Data Source: STRINGDB
SMTN
Novelty: 0.00823973
Score: 0.687
Data Source: STRINGDB
UTRN
Novelty: 0.00225431
Score: 0.665
Data Source: STRINGDB
PLS3
Novelty: 0.01113879
Score: 0.664
Data Source: STRINGDB
MYH11
Novelty: 0.00189652
Score: 0.636
Data Source: STRINGDB
PLS1
Novelty: 0.0040352
Score: 0.62
Data Source: STRINGDB
MYOCD
Novelty: 0.00397684
Score: 0.594
Data Source: STRINGDB
EHBP1
Novelty: 0.1059361
Score: 0.593
Data Source: STRINGDB
Publication Statistics
PubMed Score 19.62
PubMed score by year
PubTator Score 15.61
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MTHFNKGPSYGLSAEVKNKIASKYDHQAEEDLRNWIEEVTGMSIGPNFQLGLKDGIILCELINKLQPGSV
1-70
KKVNESSLNWPQLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTTLVALAGLAKTKGFHTTIDI
70-140
GVKYAEKQTRRFDEGKLKAGQSVIGLQMGTNKCASQAGMTAYGTRRHLYDPKMQTDKPFDQTTISLQMGT
140-210
NKGASQAGMLAPGTRRDIYDQKLTLQPVDNSTISLQMGTNKVASQKGMSVYGLGRQVYDPKYCAAPTEPV
210-280
IHNGSQGTGTNGSEISDSDYQAEYPDEYHGEYQDDYPRDYQYSDQGIDY
280-329
MTHFNKGPSYGLSAEVKNKIASKYDHQAEEDLRNWIEEVTGMSIGPNFQLGLKDGIILCELINKLQPGSVKKVNESSLNWPQLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTTLVALAGLAKTKGFHTTIDIGVKYAEKQTRRFDEGKLKAGQSVIGLQMGTNKCASQAGMTAYGTRRHLYDPKMQTDKPFDQTTISLQMGTNKGASQAGMLAPGTRRDIYDQKLTLQPVDNSTISLQMGTNKVASQKGMSVYGLGRQVYDPKYCAAPTEPVIHNGSQGTGTNGSEISDSDYQAEYPDEYHGEYQDDYPRDYQYSDQGIDY
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