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Tclin
RYR3
Ryanodine receptor 3

Protein Summary
Description
Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca(2+) release by other calcium channels. Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. Contributes to cellular calcium ion homeostasis (By similarity). Plays a role in cellular calcium signaling. The protein encoded by this gene is a ryanodine receptor, which functions to release calcium from intracellular storage for use in many cellular processes. For example, the encoded protein is involved in skeletal muscle contraction by releasing calcium from the sarcoplasmic reticulum followed by depolarization of T-tubules. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000415757
  • ENSP00000399610
  • ENSG00000198838
  • ENST00000634891
  • ENSP00000489262

Symbol
  • HBRR
  • RYR-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
trait
1
co-expressed gene
0.96
molecular function
0.95
cellular component
0.73


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.52   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 24   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.52   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 24   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
dantrolene
chemical structure image
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ryanodine receptor 3
VGNC:1882
453296
Mouse
MGI:99684
20192
Dog
ryanodine receptor 3
VGNC:45823
100686627
Horse
ryanodine receptor 3
VGNC:22644
100071830
Cow
ryanodine receptor 3
VGNC:34235
539899
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ryanodine receptor 3
Mouse
Dog
ryanodine receptor 3
Horse
ryanodine receptor 3
Cow
ryanodine receptor 3
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (18)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Ion channel transport
Reactome
Ion homeostasis
Reactome
Muscle contraction
Reactome
Stimuli-sensing channels
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Ion channel transport
Ion homeostasis
Muscle contraction
Stimuli-sensing channels
Gene Ontology Terms (26)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (78)
1 – 10 of 78
FKBP1B
Tchem
Family: Enzyme
Novelty: 0.00541222
Score: 0.983
Data Source: STRINGDB
TRDN
Tbio
Novelty: 0.00501554
Score: 0.962
Data Source: STRINGDB
ASPH
Tbio
Family: Enzyme
Novelty: 0.00291455
Score: 0.949
Data Source: STRINGDB
CALM1
Tclin
Novelty: 0.00308267
Score: 0.92
Data Source: STRINGDB
RYR2
Tclin
Family: IC
Novelty: 0.00078796
Score: 0.876
Data Source: STRINGDB
NOS1
Tchem
Family: Enzyme
Novelty: 0.00032064
Score: 0.836
Data Source: STRINGDB
FKBP1A
Tclin
Family: Enzyme
Novelty: 0.00116174
Score: 0.826
Data Source: STRINGDB
CD38
Tclin
Family: Enzyme
Novelty: 0.00034991
Score: 0.819
Data Source: STRINGDB
RYR1
Tclin
Family: IC
Novelty: 0.00077827
Score: 0.809
Data Source: STRINGDB
CALM3
Tclin
Novelty: 0.00461552
Score: 0.787
Data Source: STRINGDB
Publication Statistics
PubMed Score  203.52

PubMed score by year
PubTator Score  88.94

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer