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Tbio
NR6A1
Nuclear receptor subfamily 6 group A member 1

Protein Summary
Description
Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis (By similarity). This gene encodes an orphan nuclear receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344523
  • ENSP00000341135
  • ENSG00000148200
  • ENST00000373584
  • ENSP00000362686
  • ENST00000416460
  • ENSP00000413701
  • ENST00000487099
  • ENSP00000420267

Symbol
  • GCNF
  • RTR
  • GCNF
  • NR61
  • hRTR
  • CT150
  • GCNF1
  • hGCNF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
transcription factor binding site profile
0.97
transcription factor
0.88
kinase perturbation
0.81
transcription factor perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 218.62   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 305   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 218.62   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 305   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
2
2
76
platelet crit
2
2
2
74.5
1
1
0
7.1
71.6
appendicular lean mass
1
1
1
26.6
age at menarche
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
76
platelet crit
2
74.5
0
7.1
71.6
appendicular lean mass
1
26.6
age at menarche
1
24.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
nuclear receptor subfamily 6 group A member 1
694120
Mouse
MGI:1352459
14536
Dog
nuclear receptor subfamily 6 group A member 1
VGNC:49931
609642
Horse
nuclear receptor subfamily 6 group A member 1
VGNC:20874
100070969
Cow
nuclear receptor subfamily 6 group A member 1
VGNC:32250
541257
Species
Name
OMA
EggNOG
Inparanoid
Macaque
nuclear receptor subfamily 6 group A member 1
Mouse
Dog
nuclear receptor subfamily 6 group A member 1
Horse
nuclear receptor subfamily 6 group A member 1
Cow
nuclear receptor subfamily 6 group A member 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q15406-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Nuclear Receptor transcription pathway
Reactome
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Name
Explore in Pharos
Explore in Source
Developmental Biology
Gene expression (Transcription)
Generic Transcription Pathway
Nuclear Receptor transcription pathway
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Gene Ontology Terms (17)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (43)
1 – 10 of 43
MUL1
Tbio
Family:  Enzyme
Novelty:  0.00841786
Score:  0.969
Data Source:  STRINGDB
ATP6V0A2
Tbio
Family:  Enzyme
Novelty:  0.00504614
Score:  0.898
Data Source:  STRINGDB
UIMC1
Tbio
Novelty:  0.02039732
Score:  0.813
Data Source:  STRINGDB
POU5F1
Tbio
Family:  TF
Novelty:  0.00033974
Score:  0.808
Data Source:  STRINGDB
NANOG
Tbio
Family:  TF
Novelty:  0.00054893
Score:  0.744
Data Source:  STRINGDB
ERCC6L
Tbio
Novelty:  0.01959203
Score:  0.73
Data Source:  STRINGDB
NCOR1
Tchem
Family:  TF
Novelty:  0.0021926
Score:  0.717
Data Source:  STRINGDB
DNMT3A
Tclin
Family:  Epigenetic
Novelty:  0.00085974
Score:  0.696
Data Source:  STRINGDB
VRTN
Tdark
Novelty:  0.07572815
Score:  0.656
Data Source:  STRINGDB
RMI1
Tbio
Novelty:  0.01222442
Score:  0.626
Data Source:  STRINGDB
Publication Statistics
PubMed Score  218.62

PubMed score by year
PubTator Score  80.99

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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