Tbio RSU1 Ras suppressor protein 1

Protein Summary

Description

Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro. This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q15404
• A8KA46
• D3DRU3
• Q6FI17
• RSP-1

Gene Name

• RSU1

Ensembl ID

• ENST00000345264
• ENSP00000339521
• ENSG00000148484
• ENST00000377921
• ENSP00000367154
• ENST00000602389
• ENSP00000473588

Symbol

• RSP1
• RSP-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	0.99
virus perturbation	0.97
histone modification site profile	0.85
kinase perturbation	0.84

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.24   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 155   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.24   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0