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Tbio
TLR1
Toll-like receptor 1

Protein Summary
Description
Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852). Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308979
  • ENSP00000354932
  • ENSG00000174125
  • ENST00000502213
  • ENSP00000421259

Symbol
  • KIAA0012
  • TIL
  • CD281
  • rsc786
  • TIL. LPRS5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.89
gene perturbation
0.85
virus perturbation
0.85
biological process
0.75
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 487.52   (req: < 5)
Gene RIFs: 134   (req: <= 3)
Antibodies: 628   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 487.52   (req: >= 5)
Gene RIFs: 134   (req: > 3)
Antibodies: 628   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.1
97.8
6
5
3
1.1
96.1
7
3
0
1.1
95.2
Eczema
1
1
0
1.1
94
age at onset
2
2
1
1.1
84.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
97.8
3
1.1
96.1
0
1.1
95.2
Eczema
0
1.1
94
age at onset
1
1.1
84.6
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
toll like receptor 1
VGNC:12857
461167
Macaque
toll like receptor 1
574289
Mouse
MGI:1341295
21897
Dog
toll like receptor 1
VGNC:53247
488834
Horse
toll like receptor 1
VGNC:49284
100049577
Species
Name
OMA
EggNOG
Inparanoid
Chimp
toll like receptor 1
Macaque
toll like receptor 1
Mouse
Dog
toll like receptor 1
Horse
toll like receptor 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15399-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (84)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
Antimicrobial peptides
Reactome
Beta defensins
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing-Cross presentation
Antimicrobial peptides
Beta defensins
Class I MHC mediated antigen processing & presentation
Gene Ontology Terms (29)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (366)
1 – 10 of 366
TLR6
Tbio
Novelty: 0.00349413
p_int: 0.999999992
p_wrong: 9e-9
Score: 0.95
Data Source: BioPlex,STRINGDB
DERA
Tbio
Family: Enzyme
Novelty: 0.0079635
p_int: 0.999879482
p_ni: 0.000120515
p_wrong: 4e-9
Score: 0.213
Data Source: BioPlex,STRINGDB
ALDH16A1
Tdark
Family: Enzyme
Novelty: 0.21880567
p_int: 0.99981277
p_ni: 0.000187227
p_wrong: 4e-9
Score: 0.228
Data Source: BioPlex,STRINGDB
CNPY3
Tbio
Novelty: 0.11473132
p_int: 0.992348704
p_ni: 0.007651296
Score: 0.534
Data Source: BioPlex,STRINGDB
TBC1D24
Tbio
Novelty: 0.0161631
p_int: 0.965425722
p_ni: 0.031052098
p_wrong: 0.00352218
Score: 0.188
Data Source: BioPlex,STRINGDB
TMEM214
Tdark
Novelty: 0.32604613
p_int: 0.954282839
p_ni: 0.045717162
Data Source: BioPlex
LRP6
Tbio
Novelty: 0.00305615
p_int: 0.947609712
p_ni: 0.052390288
Data Source: BioPlex
STK11IP
Tdark
Family: Enzyme
Novelty: 0.2856954
p_int: 0.917762831
p_ni: 0.082237169
Data Source: BioPlex
TMX1
Tbio
Novelty: 0.03444237
p_int: 0.903938813
p_ni: 0.096061187
Data Source: BioPlex
COLEC12
Tbio
Novelty: 0.02882427
p_int: 0.885340938
p_ni: 0.098170101
p_wrong: 0.01648896
Score: 0.171
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  487.52

PubMed score by year
PubTator Score  360.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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