Tbio TLR1 Toll-like receptor 1

Protein Summary

Description

Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852). Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q15399
• D1CS39
• D1CS41
• O15452
• Q32MK3
• Q32MK4
• Q9UG90

Gene Name

• TLR1

Ensembl ID

• ENST00000308979
• ENSP00000354932
• ENSG00000174125
• ENST00000502213
• ENSP00000421259

Symbol

• KIAA0012
• TIL
• CD281
• rsc786
• TIL. LPRS5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.89
gene perturbation	0.85
virus perturbation	0.85
biological process	0.75
protein domain	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 659.59   (req: < 5)

Gene RIFs: 151   (req: <= 3)

Antibodies: 628   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 659.59   (req: >= 5)

Gene RIFs: 151   (req: > 3)

Antibodies: 628   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0