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Tbio
DLGAP5
Disks large-associated protein 5

Protein Summary
Description
Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000247191
  • ENSP00000247191
  • ENSG00000126787
  • ENST00000395425
  • ENSP00000378815

Symbol
  • DLG7
  • KIAA0008
  • DLG7
  • HURP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.93
histone modification site profile
0.83
co-expressed gene
0.72
small molecule perturbation
0.72
drug perturbation
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.9   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 226   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.9   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 226   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
galectin-3 measurement
1
1
1
81.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
galectin-3 measurement
1
81.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DLG associated protein 5
VGNC:7455
452920
Macaque
DLG associated protein 5
696772
Mouse
MGI:2183453
218977
Rat
RGD:1311247
289997
Dog
DLG associated protein 5
VGNC:39983
480331
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DLG associated protein 5
Macaque
DLG associated protein 5
Mouse
Rat
Dog
DLG associated protein 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q15398-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
NOTCH3 Intracellular Domain Regulates Transcription (R-HSA-9013508)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
NOTCH3 Intracellular Domain Regulates Transcription
Reactome
Signal Transduction
Reactome
Signaling by NOTCH
Reactome
Signaling by NOTCH3
Name
Explore in Pharos
Explore in Source
NOTCH3 Intracellular Domain Regulates Transcription
Signal Transduction
Signaling by NOTCH
Signaling by NOTCH3
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (262)
1 – 10 of 262
TUBB3
Tclin
Novelty: 0.00195963
p_int: 0.999999999
p_ni: 1e-9
Data Source: BioPlex
CAPS
Tbio
Novelty: 0.04549022
p_int: 0.99999996
p_ni: 4e-8
Data Source: BioPlex
B2M
Tbio
Novelty: 0.00011248
p_int: 0.99998432
p_ni: 0.00001566
p_wrong: 2e-8
Score: 0.524
Data Source: BioPlex,STRINGDB
RAN
Tbio
Family: Enzyme
Novelty: 0.00160888
p_int: 0.999922794
p_ni: 0.000050148
p_wrong: 0.000027057
Score: 0.857
Data Source: BioPlex,STRINGDB
DYDC2
Tdark
Novelty: 1.40061645
p_int: 0.999724492
p_ni: 0.000275484
p_wrong: 2.4e-8
Data Source: BioPlex
RCC1
Tbio
Novelty: 0.00260884
p_int: 0.999011341
p_ni: 0.000043546
p_wrong: 0.000945113
Score: 0.837
Data Source: BioPlex,STRINGDB
NEMP1
Tdark
Novelty: 0.37603456
p_int: 0.997209483
p_ni: 0.002729037
p_wrong: 0.00006148
Score: 0.718
Data Source: BioPlex,STRINGDB
TUBA1B
Tchem
Novelty: 0.02465964
p_int: 0.996772343
p_ni: 0.00322749
p_wrong: 1.67e-7
Score: 0.249
Data Source: BioPlex,STRINGDB
TUBA4A
Tchem
Novelty: 0.00820546
p_int: 0.974318278
p_ni: 0.025671289
p_wrong: 0.000010433
Score: 0.169
Data Source: BioPlex,STRINGDB
AURKA
Tchem
Family: Kinase
Novelty: 0.0010868
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  69.90

PubMed score by year
PubTator Score  50.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer