Tbio DLGAP5 Disks large-associated protein 5

Protein Summary

Description

Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.

Uniprot Accession IDs

• Q15398
• A8MTM6
• B4DRM8
• Q86T11
• Q8NG58
• DAP-5

Gene Name

• DLGAP5

Ensembl ID

• ENST00000247191
• ENSP00000247191
• ENSG00000126787
• ENST00000395425
• ENSP00000378815

Symbol

• DLG7
• KIAA0008
• DLG7
• HURP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.93
histone modification site profile	0.83
co-expressed gene	0.72
small molecule perturbation	0.72
drug perturbation	0.71

Protein Classes

PANTHER Classes

Protein / Transmembrane Receptor Regulatory/adaptor Protein / Disks Large-associated Protein 5

DTO Classes

Protein / Receptor / Disks Large-associated Protein 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.67   (req: < 5)

Gene RIFs: 36   (req: <= 3)

Antibodies: 226   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.67   (req: >= 5)

Gene RIFs: 36   (req: > 3)

Antibodies: 226   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0