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Tbio
PUM3
Pumilio homolog 3

Protein Summary
Description
Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress (PubMed:21266351). Binds to double-stranded RNA or DNA without sequence specificity (PubMed:25512524). Involved in development of the eye and of primordial germ cells (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397885
  • ENSP00000380982
  • ENSG00000080608

Symbol
  • cPERP-C
  • KIAA0020
  • PUF-A
  • XTP5
  • PEN
  • HA-8
  • PUF6
  • XTP5
  • PUF-A
  • HLA-HA8
  • KIAA0020
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.83   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.83   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pumilio RNA binding family member 3
VGNC:4841
464968
Macaque
pumilio RNA binding family member 3
696063
Mouse
MGI:106253
52874
Rat
RGD:1308750
294066
Dog
pumilio RNA binding family member 3
VGNC:45208
476337
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pumilio RNA binding family member 3
Macaque
pumilio RNA binding family member 3
Mouse
Rat
Dog
pumilio RNA binding family member 3
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15397-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (414)
1 – 10 of 414
HIST1H1A
Tbio
Novelty: 0.00123818
p_int: 0.999857109
p_ni: 0.000142891
Data Source: BioPlex
RPL14
Tbio
Novelty: 0.01600377
p_int: 0.999217667
p_ni: 0.000782333
Score: 0.366
Data Source: BioPlex,STRINGDB
RPL18A
Tbio
Novelty: 0.04612948
p_int: 0.99901895
p_ni: 0.00098105
Score: 0.539
Data Source: BioPlex,STRINGDB
RPL8
Tbio
Novelty: 0.01064076
p_int: 0.998054454
p_ni: 0.001945546
Score: 0.665
Data Source: BioPlex,STRINGDB
RBM34
Tdark
Novelty: 0.58131282
p_int: 0.996644852
p_ni: 0.003355148
Score: 0.95
Data Source: BioPlex,STRINGDB
RRP8
Tbio
Family: Enzyme
Novelty: 0.04922797
p_int: 0.996159257
p_ni: 0.003840743
Score: 0.933
Data Source: BioPlex,STRINGDB
RPL26L1
Tdark
Novelty: 0.75408617
p_int: 0.99474091
p_ni: 0.00525909
Score: 0.36
Data Source: BioPlex,STRINGDB
RPL28
Tbio
Novelty: 0.03136035
p_int: 0.993801334
p_ni: 0.006198666
Score: 0.335
Data Source: BioPlex,STRINGDB
RPL30
Tbio
Novelty: 0.0134194
p_int: 0.993226897
p_ni: 0.006773103
Score: 0.371
Data Source: BioPlex,STRINGDB
ZNF2
Tbio
Family: TF
Novelty: 0.01062543
p_int: 0.99252828
p_ni: 0.00747172
Score: 0.183
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  44.83

PubMed score by year
PubTator Score  2622.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer