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Tchem
SF3B3
Splicing factor 3B subunit 3

Protein Summary
Description
Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome (PubMed:10490618, PubMed:10882114, PubMed:27720643, PubMed:28781166). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077). This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302516
  • ENSP00000305790
  • ENSG00000189091

Symbol
  • KIAA0017
  • SAP130
  • RSE1
  • SAP130
  • SF3b130
  • STAF130
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
0.95
kinase perturbation
0.93
protein complex
0.93
microRNA
0.86


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.55   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 287   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.55   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 287   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (372)
PHF5A
Tbio
Family:  Epigenetic
Novelty:  0.02989472
p_int:  0.996830341
p_ni:  0.003169659
Score:  0.999
Data Source:  BioPlex,STRINGDB
CCDC97
Tdark
Novelty:  2.36351796
p_int:  0.996364004
p_ni:  0.003635996
Score:  0.99
Data Source:  BioPlex,STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.982211613
p_ni:  0.017788387
Score:  0.998
Data Source:  BioPlex,STRINGDB
SNRPB2
Tbio
Novelty:  0.17219587
p_int:  0.883397166
p_ni:  0.116602834
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRPA1
Tbio
Novelty:  0.01232044
p_int:  0.872007959
p_ni:  0.127992041
Score:  0.999
Data Source:  BioPlex,STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.999
Data Source:  STRINGDB
PRPF6
Tbio
Novelty:  0.02818008
Score:  0.999
Data Source:  STRINGDB
PRPF8
Tbio
Novelty:  0.01717158
Score:  0.999
Data Source:  STRINGDB
SF3B2
Tbio
Novelty:  0.0271365
Score:  0.999
Data Source:  STRINGDB
SNRPD2
Tbio
Novelty:  0.02519503
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Reactome
mRNA Splicing - Minor Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
1
1
42.3
comparative body size at age 10, self-reported
1
1
1
39.6
apolipoprotein B measurement
1
1
1
39.6
total cholesterol measurement
1
1
1
33.1
low density lipoprotein cholesterol measurement
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
42.3
comparative body size at age 10, self-reported
1
39.6
apolipoprotein B measurement
1
39.6
total cholesterol measurement
1
33.1
low density lipoprotein cholesterol measurement
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
splicing factor 3b subunit 3
VGNC:5918
454216
Macaque
splicing factor 3b subunit 3
708939
Mouse
MGI:1289341
101943
Rat
RGD:1311636
292019
Dog
splicing factor 3b subunit 3
VGNC:46071
479659
Species
Name
OMA
EggNOG
Inparanoid
Chimp
splicing factor 3b subunit 3
Macaque
splicing factor 3b subunit 3
Mouse
Rat
Dog
splicing factor 3b subunit 3
Publication Statistics
PubMed Score 36.55
PubMed score by year
PubTator Score 15.31
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title