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Tchem
P2RY14
P2Y purinoceptor 14

Protein Summary
Description
Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP. The product of this gene belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309170
  • ENSP00000308361
  • ENSG00000174944
  • ENST00000424796
  • ENSP00000408733

Symbol
  • GPR105
  • KIAA0001
  • P2Y14
  • BPR105
  • GPR105
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.9
PubMedID
0.67
microRNA
0.6
cell type or tissue
0.53
molecular function
0.53


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.55   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 223   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.55   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 223   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 41
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
74.6
myeloid white cell count
1
1
1
74.2
leukocyte count
1
1
1
64.4
eosinophil count
2
1
2
56.8
monocyte count
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
74.6
myeloid white cell count
1
74.2
leukocyte count
1
64.4
eosinophil count
2
56.8
monocyte count
1
42.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
purinergic receptor P2Y14
709857
Mouse
MGI:2155705
140795
Rat
RGD:70912
171108
Dog
purinergic receptor P2Y14
VGNC:44216
485717
Horse
purinergic receptor P2Y14
VGNC:21112
100050149
Species
Name
OMA
EggNOG
Inparanoid
Macaque
purinergic receptor P2Y14
Mouse
Rat
Dog
purinergic receptor P2Y14
Horse
purinergic receptor P2Y14
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15391-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Nucleotide-like (purinergic) receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Nucleotide-like (purinergic) receptors
Protein-Protein Interactions (256)
1 – 10 of 256
ATP12A
Tchem
Family:  Transporter
Novelty:  0.00008793
p_int:  0.890022518
p_ni:  0.109977481
p_wrong:  1e-9
Score:  0.235
Data Source:  BioPlex,STRINGDB
ADORA3
Tchem
Family:  GPCR
Novelty:  0.00089511
Score:  0.955
Data Source:  STRINGDB
TMIGD3
Tchem
Novelty:  0.00089511
Score:  0.955
Data Source:  STRINGDB
ADORA1
Tclin
Family:  GPCR
Novelty:  0.00043697
Score:  0.946
Data Source:  STRINGDB
HTR1B
Tclin
Family:  GPCR
Novelty:  0.00073663
Score:  0.938
Data Source:  STRINGDB
S1PR4
Tclin
Family:  GPCR
Novelty:  0.01523676
Score:  0.936
Data Source:  STRINGDB
P2RY13
Tchem
Family:  GPCR
Novelty:  0.01511227
Score:  0.931
Data Source:  STRINGDB
P2RY4
Tchem
Family:  GPCR
Novelty:  0.00903213
Score:  0.926
Data Source:  STRINGDB
RXFP4
Tchem
Family:  GPCR
Novelty:  0.05054041
Score:  0.924
Data Source:  STRINGDB
SUCNR1
Tchem
Family:  GPCR
Novelty:  0.01482891
Score:  0.917
Data Source:  STRINGDB
Publication Statistics
PubMed Score  78.55

PubMed score by year
PubTator Score  54.76

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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