Tbio MTFR1 Mitochondrial fission regulator 1

Protein Summary

Description

May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity). This gene encodes a mitochondrial protein that is characterized by a poly-proline rich region. A chicken homolog of this protein promotes mitochondrial fission and the mouse homolog protects cells from oxidative stress. A related pseudogene of this gene is found on chromosome X. [provided by RefSeq, Mar 2009]

Uniprot Accession IDs

• Q15390
• E7EP84
• Q6IB94
• Q7Z669
• Q86XH5
• Q8IVD7

Gene Name

• MTFR1

Ensembl ID

• ENST00000262146
• ENSP00000262146
• ENSG00000066855
• ENST00000458689
• ENSP00000391502

Symbol

• CHPPR
• FAM54A2
• KIAA0009
• CHPPR
• FAM54A2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.96
transcription factor binding site profile	0.8
virus perturbation	0.79
histone modification site profile	0.72
transcription factor	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.81   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 94   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.81   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0