Tbio TOMM20 Mitochondrial import receptor subunit TOM20 homolog

Protein Summary

Description

Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity).

Uniprot Accession IDs

• Q15388
• A8K195
• Q498B3
• Q6IBT4

Gene Name

• TOMM20

Ensembl ID

• ENST00000366607
• ENSP00000355566
• ENSG00000173726

Symbol

• KIAA0016
• MAS20
• MOM19
• TOM20

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
transcription factor perturbation	0.94
virus perturbation	0.94
transcription factor binding site profile	0.93
disease perturbation	0.87

Protein Classes

PANTHER Classes

Protein / Transporter / Mitochondrial Import Receptor Subunit Tom20 Homolog

DTO Classes

Protein / Transporter / Mitochondrial Import Receptor Subunit Tom20 Homolog

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 451.06   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 192   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 451.06   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 192   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0