Tbio UBE3C Ubiquitin-protein ligase E3C

Protein Summary

Description

E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.

Uniprot Accession IDs

• Q15386
• A4D235
• A6NCP3
• Q8TC15
• Q96CR4
• Q9UDU3

Gene Name

• UBE3C

Ensembl ID

• ENST00000348165
• ENSP00000309198
• ENSG00000009335
• ENST00000389103
• ENSP00000373755
• ENST00000611269
• ENSP00000481584

Symbol

• KIAA0010
• KIAA10
• HECTH2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.9
virus perturbation	0.9
microRNA	0.76
kinase perturbation	0.71
transcription factor binding site profile	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.19   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 138   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.19   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0