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Tbio
RHEB
GTP-binding protein Rheb

Protein Summary
Description
Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity. This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262187
  • ENSP00000262187
  • ENSG00000106615

Symbol
  • RHEB2
  • RHEB2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
molecular function
0.97
transcription factor perturbation
0.94
interacting protein
0.92
co-expressed gene
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 327.53   (req: < 5)
Gene RIFs: 73   (req: <= 3)
Antibodies: 429   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 327.53   (req: >= 5)
Gene RIFs: 73   (req: > 3)
Antibodies: 429   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
64.3
albuminuria
1
1
0
30.5
17.8
smoking status measurement
1
1
0
6.5
2.8
low density lipoprotein cholesterol measurement
1
1
0
6.5
2.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
64.3
albuminuria
0
30.5
17.8
smoking status measurement
0
6.5
2.8
low density lipoprotein cholesterol measurement
0
6.5
2.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:97912
19744
Rat
RGD:621840
26954
Dog
Ras homolog, mTORC1 binding
VGNC:45551
475545
Horse
Ras homolog, mTORC1 binding
VGNC:22367
100064440
Cow
Ras homolog, mTORC1 binding
VGNC:33939
528204
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
Ras homolog, mTORC1 binding
Horse
Ras homolog, mTORC1 binding
Cow
Ras homolog, mTORC1 binding
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15382-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (193)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Energy dependent regulation of mTOR by LKB1-AMPK
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Energy dependent regulation of mTOR by LKB1-AMPK
Gene expression (Transcription)
Generic Transcription Pathway
Gene Ontology Terms (20)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (203)
1 – 10 of 203
SPATA19
Tbio
Novelty:  0.06203122
p_int:  0.99955999
p_ni:  0.000440008
p_wrong:  2e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
NEDD9
Tbio
Novelty:  0.00539079
p_int:  0.998654713
p_ni:  0.001345278
p_wrong:  9e-9
Score:  0.222
Data Source:  BioPlex,STRINGDB
NFATC2IP
Tbio
Novelty:  0.02974299
p_int:  0.987911224
p_ni:  0.012088776
Score:  0.185
Data Source:  BioPlex,STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
p_int:  0.986098497
p_ni:  0.013901503
Score:  0.324
Data Source:  BioPlex,STRINGDB
UBB
Tbio
Novelty:  0.00661254
p_int:  0.984733066
p_ni:  0.015266934
Score:  0.262
Data Source:  BioPlex,STRINGDB
IL20RA
Tbio
Novelty:  0.02416816
p_int:  0.947160445
p_ni:  0.052839555
Data Source:  BioPlex
TNF
Tclin
Novelty:  0.00001457
p_int:  0.930997463
p_ni:  0.069002369
p_wrong:  1.69e-7
Score:  0.27
Data Source:  BioPlex,STRINGDB
LAMP2
Tbio
Novelty:  0.00168009
p_int:  0.929893845
p_ni:  0.070106155
Score:  0.509
Data Source:  BioPlex,STRINGDB
SRPRB
Tbio
Novelty:  0.04735362
p_int:  0.913265161
p_ni:  0.086734839
Data Source:  BioPlex
SLC15A1
Tchem
Family:  Transporter
Novelty:  0.00149723
p_int:  0.91147015
p_ni:  0.088425922
p_wrong:  0.000103928
Data Source:  BioPlex
Publication Statistics
PubMed Score  327.53

PubMed score by year
PubTator Score  141.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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