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Tbio
ELOB
Elongin-B

Protein Summary
Description
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7638163). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity). The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RB ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262306
  • ENSP00000262306
  • ENSG00000103363
  • ENST00000409906
  • ENSP00000386652

Symbol
  • TCEB2
  • SIII
  • TCEB2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.27   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 313   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.27   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 313   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (497)
VHL
Tchem
Family:  Enzyme
Novelty:  0.00285782
p_int:  0.998329712
p_ni:  0.001670288
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
NRBP1
Tbio
Family:  Kinase
Novelty:  0.05902656
p_int:  0.987383982
p_ni:  0.012616018
Score:  0.66
Data Source:  BioPlex,STRINGDB
ANKRD9
Tdark
Novelty:  0.43181793
p_int:  0.968842909
p_ni:  0.031157091
Score:  0.901
Data Source:  BioPlex,STRINGDB
ASB6
Tdark
Novelty:  0.32074223
p_int:  0.905594434
p_ni:  0.094405566
Score:  0.936
Data Source:  BioPlex,STRINGDB
KLHDC2
Tbio
Novelty:  0.01485159
p_int:  0.871830218
p_ni:  0.128169782
Score:  0.229
Data Source:  BioPlex,STRINGDB
ASB9
Tbio
Novelty:  0.18287435
p_int:  0.798468834
p_ni:  0.201531166
Score:  0.993
Data Source:  BioPlex,STRINGDB
ELOC
Tbio
Novelty:  0.00964847
Score:  0.999
Data Source:  Reactome,STRINGDB
CUL2
Tbio
Novelty:  0.00512916
Score:  0.999
Data Source:  Reactome,STRINGDB
CUL5
Tbio
Novelty:  0.00792494
Score:  0.999
Data Source:  Reactome,STRINGDB
HIF1A
Tchem
Family:  TF
Novelty:  0.00011503
Score:  0.998
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (92)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 39
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Axon guidance
Reactome
Cellular response to hypoxia
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Axon guidance
Cellular response to hypoxia
Cellular responses to external stimuli
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
4
4
87.5
body mass index
2
2
2
85
blood protein measurement
2
2
2
82
eosinophil percentage of leukocytes
2
2
2
77.8
body height
1
1
1
68.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
87.5
body mass index
2
85
blood protein measurement
2
82
eosinophil percentage of leukocytes
2
77.8
body height
1
68.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transcription elongation factor B polypeptide 2-like
739191
Mouse
MGI:1914923
67673
Rat
RGD:621200
81807
Rat
Dog
elongin B
VGNC:40316
479873
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transcription elongation factor B polypeptide 2-like
Mouse
Rat
Rat
Dog
elongin B
Publication Statistics
PubMed Score 57.27
PubMed score by year
PubTator Score 58.92
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title