Protein Summary
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7638163). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity). The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RB ...more
- ENST00000262306
- ENSP00000262306
- ENSG00000103363
- ENST00000409906
- ENSP00000386652
- TCEB2
- SIII
- TCEB2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 57.27 (req: < 5)
Gene RIFs: 14 (req: <= 3)
Antibodies: 313 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 57.27 (req: >= 5)
Gene RIFs: 14 (req: > 3)
Antibodies: 313 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (497)
VHL
Family: Enzyme
Novelty: 0.00285782
p_int: 0.998329712
p_ni: 0.001670288
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
NRBP1
Family: Kinase
Novelty: 0.05902656
p_int: 0.987383982
p_ni: 0.012616018
Score: 0.66
Data Source: BioPlex,STRINGDB
ANKRD9
Novelty: 0.43181793
p_int: 0.968842909
p_ni: 0.031157091
Score: 0.901
Data Source: BioPlex,STRINGDB
ASB6
Novelty: 0.32074223
p_int: 0.905594434
p_ni: 0.094405566
Score: 0.936
Data Source: BioPlex,STRINGDB
KLHDC2
Novelty: 0.01485159
p_int: 0.871830218
p_ni: 0.128169782
Score: 0.229
Data Source: BioPlex,STRINGDB
ASB9
Novelty: 0.18287435
p_int: 0.798468834
p_ni: 0.201531166
Score: 0.993
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (92)
Reactome (39)
KEGG (5)
PathwayCommons (2)
UniProt (1)
WikiPathways (45)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing: Ubiquitination & Proteasome degradation | ||||
Reactome | Axon guidance | ||||
Reactome | Cellular response to hypoxia | ||||
Reactome | Cellular responses to external stimuli | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Antigen processing: Ubiquitination & Proteasome degradation | ||||
Axon guidance | ||||
Cellular response to hypoxia | ||||
Cellular responses to external stimuli | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (1)
Components (6)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
eosinophil count | 4 | 4 | 4 | 87.5 | |||||
body mass index | 2 | 2 | 2 | 85 | |||||
blood protein measurement | 2 | 2 | 2 | 82 | |||||
eosinophil percentage of leukocytes | 2 | 2 | 2 | 77.8 | |||||
body height | 1 | 1 | 1 | 68.7 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
eosinophil count | 4 | 87.5 | |||||
body mass index | 2 | 85 | |||||
blood protein measurement | 2 | 82 | |||||
eosinophil percentage of leukocytes | 2 | 77.8 | |||||
body height | 1 | 68.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | transcription elongation factor B polypeptide 2-like | 739191 | ||||||
Mouse | MGI:1914923 | 67673 | ||||||
Rat | RGD:621200 | 81807 | ||||||
Rat | ||||||||
Dog | elongin B | VGNC:40316 | 479873 | |||||
Publication Statistics
PubMed Score 57.27
PubMed score by year
PubTator Score 58.92
PubTator score by year
Related Publications
Text Mined References (58)
GeneRif Annotations (14)
Items per page:
0 of 0
PMID | Year | Title |
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