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Tbio
PCBP2
Poly(rC)-binding protein 2

Protein Summary
Description
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943). The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359282
  • ENSP00000352228
  • ENSG00000197111
  • ENST00000359462
  • ENSP00000352438
  • ENST00000437231
  • ENSP00000390304
  • ENST00000439930
  • ENSP00000408949
  • ENST00000447282
  • ENSP00000394116
  • ENST00000455667
  • ENSP00000388008
  • ENST00000546463
  • ENSP00000448762
  • ENST00000548933
  • ENSP00000449062
  • ENST00000552296
  • ENSP00000448927
  • ENST00000552819
  • ENSP00000449070

Symbol
  • HNRPE2
  • HNRNPE2
  • hnRNP-E2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
1
protein complex
1
transcription factor perturbation
0.94


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.25   (req: < 5)
Gene RIFs: 53   (req: <= 3)
Antibodies: 245   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.25   (req: >= 5)
Gene RIFs: 53   (req: > 3)
Antibodies: 245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
56.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
56.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
poly(rC) binding protein 2
VGNC:8490
467006
Macaque
poly(rC) binding protein 2
703175
Mouse
MGI:108202
18521
Rat
RGD:1309626
363005
Dog
poly(rC) binding protein 2
477596
Species
Name
OMA
EggNOG
Inparanoid
Chimp
poly(rC) binding protein 2
Macaque
poly(rC) binding protein 2
Mouse
Rat
Dog
poly(rC) binding protein 2
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15366-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (R-HSA-168928)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism of RNA
Reactome
Negative regulators of DDX58/IFIH1 signaling
Name
Explore in Pharos
Explore in Source
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Immune System
Innate Immune System
Metabolism of RNA
Negative regulators of DDX58/IFIH1 signaling
Gene Ontology Terms (21)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (363)
1 – 10 of 363
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.998
Data Source: STRINGDB
ELAVL1
Tchem
Novelty: 0.00110045
Score: 0.996
Data Source: STRINGDB
SRSF3
Tbio
Novelty: 0.01015895
Score: 0.991
Data Source: STRINGDB
PTBP1
Tbio
Novelty: 0.00184728
Score: 0.989
Data Source: STRINGDB
HNRNPL
Tbio
Novelty: 0.01048413
Score: 0.988
Data Source: STRINGDB
HNRNPA1
Tchem
Novelty: 0.0020871
Score: 0.986
Data Source: STRINGDB
HNRNPA2B1
Tbio
Novelty: 0.00404935
Score: 0.979
Data Source: STRINGDB
PCBP1
Tbio
Novelty: 0.00906713
Score: 0.978
Data Source: STRINGDB
HNRNPK
Tbio
Novelty: 0.00354731
Score: 0.978
Data Source: STRINGDB
HNRNPC
Tbio
Novelty: 0.00136097
Score: 0.978
Data Source: STRINGDB
Publication Statistics
PubMed Score  140.25

PubMed score by year
PubTator Score  85.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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