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Tbio
PCBP2
Poly(rC)-binding protein 2

Protein Summary
Description
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943). The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359282
  • ENSP00000352228
  • ENSG00000197111
  • ENST00000359462
  • ENSP00000352438
  • ENST00000437231
  • ENSP00000390304
  • ENST00000439930
  • ENSP00000408949
  • ENST00000447282
  • ENSP00000394116
  • ENST00000455667
  • ENSP00000388008
  • ENST00000546463
  • ENSP00000448762
  • ENST00000548933
  • ENSP00000449062
  • ENST00000552296
  • ENSP00000448927
  • ENST00000552819
  • ENSP00000449070

Symbol
  • HNRPE2
  • HNRNPE2
  • hnRNP-E2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
1
protein complex
1
transcription factor perturbation
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.89   (req: < 5)
Gene RIFs: 53   (req: <= 3)
Antibodies: 245   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.89   (req: >= 5)
Gene RIFs: 53   (req: > 3)
Antibodies: 245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0