Tbio PCBP2 Poly(rC)-binding protein 2

Protein Summary

Description

Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943). The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. This gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2018]

Uniprot Accession IDs

• Q15366
• A8K7X6
• B4DXP5
• F8VYL7
• G3V0E8
• I6L8F9
• Q32Q82
• Q59HD4
• Q68Y55
• Q6IPF4
• Q6PKG5

Gene Name

• PCBP2

Ensembl ID

• ENST00000359282
• ENSP00000352228
• ENSG00000197111
• ENST00000359462
• ENSP00000352438
• ENST00000437231
• ENSP00000390304
• ENST00000439930
• ENSP00000408949
• ENST00000447282
• ENSP00000394116
• ENST00000455667
• ENSP00000388008
• ENST00000546463
• ENSP00000448762
• ENST00000548933
• ENSP00000449062
• ENST00000552296
• ENSP00000448927
• ENST00000552819
• ENSP00000449070

Symbol

• HNRPE2
• HNRNPE2
• hnRNP-E2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	1
kinase perturbation	1
protein complex	1
transcription factor perturbation	0.94

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribonucleoprotein / Poly(rc)-binding Protein 2

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Poly(rc)-binding Protein 2

Protein / Enzyme Modulator / Poly(rc)-binding Protein 2

Protein / ... / Serine Protease / Poly(rc)-binding Protein 2

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Poly(rc)-binding Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.89   (req: < 5)

Gene RIFs: 75   (req: <= 3)

Antibodies: 245   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.89   (req: >= 5)

Gene RIFs: 75   (req: > 3)

Antibodies: 245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0