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Tbio
PCBP2
Poly(rC)-binding protein 2

Protein Summary
Description
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943). The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359282
  • ENSP00000352228
  • ENSG00000197111
  • ENST00000359462
  • ENSP00000352438
  • ENST00000437231
  • ENSP00000390304
  • ENST00000439930
  • ENSP00000408949
  • ENST00000447282
  • ENSP00000394116
  • ENST00000455667
  • ENSP00000388008
  • ENST00000546463
  • ENSP00000448762
  • ENST00000548933
  • ENSP00000449062
  • ENST00000552296
  • ENSP00000448927
  • ENST00000552819
  • ENSP00000449070

Symbol
  • HNRPE2
  • HNRNPE2
  • hnRNP-E2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
1
protein complex
1
transcription factor perturbation
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.25   (req: < 5)
Gene RIFs: 53   (req: <= 3)
Antibodies: 245   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.25   (req: >= 5)
Gene RIFs: 53   (req: > 3)
Antibodies: 245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
56.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
56.5
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (R-HSA-168928)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism of RNA
Reactome
Negative regulators of DDX58/IFIH1 signaling
Name
Explore in Pharos
Explore in Source
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Immune System
Innate Immune System
Metabolism of RNA
Negative regulators of DDX58/IFIH1 signaling
Gene Ontology Terms (21)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (363)
1 – 10 of 363
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.998
Data Source: STRINGDB
ELAVL1
Tchem
Novelty: 0.00110045
Score: 0.996
Data Source: STRINGDB
SRSF3
Tbio
Novelty: 0.01015895
Score: 0.991
Data Source: STRINGDB
PTBP1
Tbio
Novelty: 0.00184728
Score: 0.989
Data Source: STRINGDB
HNRNPL
Tbio
Novelty: 0.01048413
Score: 0.988
Data Source: STRINGDB
HNRNPA1
Tchem
Novelty: 0.0020871
Score: 0.986
Data Source: STRINGDB
HNRNPA2B1
Tbio
Novelty: 0.00404935
Score: 0.979
Data Source: STRINGDB
PCBP1
Tbio
Novelty: 0.00906713
Score: 0.978
Data Source: STRINGDB
HNRNPK
Tbio
Novelty: 0.00354731
Score: 0.978
Data Source: STRINGDB
HNRNPC
Tbio
Novelty: 0.00136097
Score: 0.978
Data Source: STRINGDB
Publication Statistics
PubMed Score  140.25

PubMed score by year
PubTator Score  85.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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