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Tbio
TMED2
Transmembrane emp24 domain-containing protein 2

Protein Summary
Description
Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golg ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262225
  • ENSP00000262225
  • ENSG00000086598

Symbol
  • RNP24
  • p24
  • P24A
  • RNP24
  • p24b1
  • p24beta1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.91
interacting protein
0.89
histone modification site profile
0.84
transcription factor binding site profile
0.84
disease perturbation
0.79


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.45   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.45   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1929269
56334
Rat
RGD:69243
65165
Dog
transmembrane p24 trafficking protein 2
100687986
Cow
transmembrane p24 trafficking protein 2
100140040
Pig
transmembrane p24 trafficking protein 2
100625917
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
transmembrane p24 trafficking protein 2
Cow
transmembrane p24 trafficking protein 2
Pig
transmembrane p24 trafficking protein 2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (17)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
COPII-mediated vesicle transport
Reactome
Cargo concentration in the ER
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-dependent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
COPII-mediated vesicle transport
Cargo concentration in the ER
Gene Ontology Terms (32)
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
HGNC
Inferred from Sequence or structural Similarity (ISS)
HGNC
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (274)
1 – 10 of 274
GOLGB1
Tbio
Novelty: 0.00943584
p_int: 0.999989163
p_ni: 0.000010837
Score: 0.924
Data Source: BioPlex,STRINGDB
TMED4
Tdark
Novelty: 0.22372593
p_int: 0.999985745
p_ni: 0.000014255
Score: 0.983
Data Source: BioPlex,STRINGDB
TMED7
Tdark
Novelty: 0.31193294
p_int: 0.999905695
p_ni: 0.000094305
Score: 0.969
Data Source: BioPlex,STRINGDB
TMED3
Tbio
Novelty: 0.06696993
p_int: 0.999600247
p_ni: 0.000399753
Score: 0.99
Data Source: BioPlex,STRINGDB
DNAJC30
Tdark
Novelty: 0.57178901
p_int: 0.99954503
p_ni: 0.000454957
p_wrong: 1.3e-8
Score: 0.195
Data Source: BioPlex,STRINGDB
USP22
Tbio
Family: Enzyme
Novelty: 0.01416662
p_int: 0.999529037
p_ni: 0.000470961
p_wrong: 2e-9
Data Source: BioPlex
FGFRL1
Tbio
Novelty: 0.02178846
p_int: 0.998122648
p_ni: 0.00184115
p_wrong: 0.000036202
Data Source: BioPlex
ATP9A
Tbio
Family: Transporter
Novelty: 0.15755352
p_int: 0.998083373
p_ni: 0.001916573
p_wrong: 5.4e-8
Score: 0.338
Data Source: BioPlex,STRINGDB
PNPT1
Tbio
Family: Enzyme
Novelty: 0.00339969
p_int: 0.994173575
p_ni: 0.005826425
Score: 0.202
Data Source: BioPlex,STRINGDB
TMED1
Tbio
Novelty: 0.11862267
p_int: 0.992742949
p_ni: 0.00725705
p_wrong: 1e-9
Score: 0.553
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  31.45

PubMed score by year
PubTator Score  2144.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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