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Tchem
RPS6KA2
Ribosomal protein S6 kinase alpha-2

Protein Summary
Description
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternative splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265678
  • ENSP00000265678
  • ENSG00000071242
  • ENST00000503859
  • ENSP00000427015

Symbol
  • MAPKAPK1C
  • RSK3
  • RSK
  • HU-2
  • RSK3
  • p90RSK2
  • p90-RSK3
  • pp90RSK3
  • MAPKAPK1C
  • S6K-alpha
  • S6K-alpha2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
biological process
0.96
disease perturbation
0.96
molecular function
0.96
transcription factor perturbation
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 267.62   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 479   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 267.62   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 479   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 136
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1