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Tchem
RPS6KA2
Ribosomal protein S6 kinase alpha-2

Protein Summary
Description
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternative splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265678
  • ENSP00000265678
  • ENSG00000071242
  • ENST00000503859
  • ENSP00000427015

Symbol
  • MAPKAPK1C
  • RSK3
  • RSK
  • HU-2
  • RSK3
  • p90RSK2
  • p90-RSK3
  • pp90RSK3
  • MAPKAPK1C
  • S6K-alpha
  • S6K-alpha2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
biological process
0.96
disease perturbation
0.96
molecular function
0.96
transcription factor perturbation
0.94


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 212.22   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 479   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 212.22   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 479   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 128
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
sunitinib
chemical structure image
Active Ligands (128)
1 – 10 of 128
CHEMBL388978
chemical structure image
CHEMBL495727
chemical structure image
CHEMBL2064666
chemical structure image
CHEMBL6291,CHEMBL1591531
chemical structure image
BI-D1870
chemical structure image
CHEMBL1933288
chemical structure image
CHEMBL1933290
chemical structure image
CHEMBL1933145
chemical structure image
CHEMBL1938792
chemical structure image
CHEMBL1933283
chemical structure image
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
viral load
1
1
1
60.1
HIV-1 infection
1
1
1
60.1
self reported educational attainment
1
1
1
57.8
1
1
0
1.1
8.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
viral load
1
60.1
HIV-1 infection
1
60.1
self reported educational attainment
1
57.8
0
1.1
8.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ribosomal protein S6 kinase A2
716899
Mouse
MGI:1342290
20112
Rat
RGD:620676
117269
Dog
ribosomal protein S6 kinase A2
VGNC:45739
612448
Horse
ribosomal protein S6 kinase A2
VGNC:22558
100050176
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ribosomal protein S6 kinase A2
Mouse
Rat
Dog
ribosomal protein S6 kinase A2
Horse
ribosomal protein S6 kinase A2
Pathways (109)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 49
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Axon guidance
Reactome
CREB phosphorylation
Reactome
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Reactome
Cellular Senescence
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Axon guidance
CREB phosphorylation
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Cellular Senescence
Gene Ontology Terms (15)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (122)
1 – 10 of 122
CSNK2B
Tbio
Family: Kinase
Novelty: 0.00152367
p_int: 0.999993029
p_ni: 0.000006971
Score: 0.245
Data Source: BioPlex,STRINGDB
MISP
Tbio
Novelty: 0.02030151
p_int: 0.999957614
p_ni: 0.000042316
p_wrong: 7e-8
Score: 0.175
Data Source: BioPlex,STRINGDB
FYN
Tclin
Family: Kinase
Novelty: 0.00072167
p_int: 0.999930595
p_ni: 0.000069404
Score: 0.212
Data Source: BioPlex,STRINGDB
IL17RA
Tclin
Novelty: 0.00416706
p_int: 0.999792957
p_ni: 0.000206692
p_wrong: 3.52e-7
Data Source: BioPlex
TRIM11
Tbio
Family: Enzyme
Novelty: 0.02243955
p_int: 0.999669224
p_ni: 0.000330496
p_wrong: 2.8e-7
Data Source: BioPlex
FGFR2
Tclin
Family: Kinase
Novelty: 0.00066613
p_int: 0.999637971
p_ni: 0.000352996
p_wrong: 0.000009033
Score: 0.224
Data Source: BioPlex,STRINGDB
STRADB
Tbio
Family: Kinase
Novelty: 0.03532206
p_int: 0.986532204
p_ni: 0.013103353
p_wrong: 0.000364444
Score: 0.195
Data Source: BioPlex,STRINGDB
TAGAP
Tbio
Family: Enzyme
Novelty: 0.04450409
p_int: 0.913336798
p_ni: 0.08265458
p_wrong: 0.004008622
Data Source: BioPlex
SPRED2
Tbio
Novelty: 0.04447225
p_int: 0.825155894
p_ni: 0.007477471
p_wrong: 0.167366636
Score: 0.221
Data Source: BioPlex,STRINGDB
IRGC
Tbio
Family: Enzyme
Novelty: 0.10743948
p_int: 0.804566277
p_ni: 0.002829225
p_wrong: 0.192604498
Score: 0.173
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  212.22

PubMed score by year
PubTator Score  148.26

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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