You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
LLGL1
Lethal(2) giant larvae protein homolog 1

Protein Summary
Description
Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. This gene encodes a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316843
  • ENSP00000321537
  • ENSG00000131899
  • ENST00000640494
  • ENSP00000492144
  • ENSG00000284137

Symbol
  • DLG4
  • HUGL
  • HUGL1
  • DLG4
  • HUGL
  • LLGL
  • Lgl1
  • Mgl1
  • HUGL1
  • HUGL-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
histone modification site profile
0.75
interacting protein
0.75
kinase perturbation
0.71
cellular component
0.68


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.1   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.1   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LLGL1, scribble cell polarity complex component
VGNC:10516
468183
Macaque
LLGL1, scribble cell polarity complex component
707405
Mouse
MGI:102682
16897
Rat
RGD:3012
54265
Dog
LLGL1, scribble cell polarity complex component
VGNC:42704
489538
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LLGL1, scribble cell polarity complex component
Macaque
LLGL1, scribble cell polarity complex component
Mouse
Rat
Dog
LLGL1, scribble cell polarity complex component
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q15334-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Tight junction
KEGG
Hippo signaling pathway
KEGG
Human papillomavirus infection
Name
Explore in Pharos
Explore in Source
Tight junction
Hippo signaling pathway
Human papillomavirus infection
Protein-Protein Interactions (79)
1 – 10 of 79
PARD6B
Tbio
Novelty: 0.08495161
p_int: 0.999917843
p_ni: 0.000082157
Score: 0.975
Data Source: BioPlex,STRINGDB
PRKCZ
Tchem
Family: Kinase
Novelty: 0.00201366
p_int: 0.999421931
p_ni: 0.000578069
Score: 0.922
Data Source: BioPlex,STRINGDB
KBTBD7
Tdark
Novelty: 0.4947466
p_int: 0.78213679
p_ni: 0.21786321
Score: 0.318
Data Source: BioPlex,STRINGDB
PRKCI
Tchem
Family: Kinase
Novelty: 0.0076377
Score: 0.947
Data Source: STRINGDB
SCRIB
Tbio
Novelty: 0.01099525
Score: 0.935
Data Source: STRINGDB
DLG3
Tbio
Novelty: 0.01196565
Score: 0.926
Data Source: STRINGDB
DLG1
Tbio
Novelty: 0.0050926
Score: 0.926
Data Source: STRINGDB
PARD6A
Tbio
Novelty: 0.05667035
Score: 0.902
Data Source: STRINGDB
BAZ2A
Tchem
Family: TF; Epigenetic
Novelty: 0.00478642
Score: 0.895
Data Source: STRINGDB
DLG2
Tbio
Novelty: 0.00999909
Score: 0.883
Data Source: STRINGDB
Publication Statistics
PubMed Score  64.10

PubMed score by year
PubTator Score  475.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer