Tbio LLGL1 Lethal(2) giant larvae protein homolog 1

Protein Summary

Description

Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. This gene encodes a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q15334
• A7MBM7
• O00188
• Q58F11
• Q86UK6
• LLGL

Gene Name

• LLGL1

Ensembl ID

• ENST00000316843
• ENSP00000321537
• ENSG00000131899
• ENST00000640494
• ENSP00000492144
• ENSG00000284137

Symbol

• DLG4
• HUGL
• HUGL1
• DLG4
• HUGL
• LLGL
• Lgl1
• Mgl1
• HUGL1
• HUGL-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
histone modification site profile	0.75
interacting protein	0.75
kinase perturbation	0.71
cellular component	0.68

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Membrane Trafficking Regulatory Protein / Lethal(2) Giant Larvae Protein Homolog 1

DTO Classes

Protein / Transporter / Membrane Trafficking Regulatory Protein / Lethal(2) Giant Larvae Protein Homolog 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.63   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 177   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.63   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0