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Tbio
KRT31
Keratin, type I cuticular Ha1

Protein Summary
Description
The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251645
  • ENSP00000251645
  • ENSG00000094796
  • ENST00000573281
  • ENSP00000460739
  • ENSG00000262993

Symbol
  • HHA1
  • HKA1
  • KRTHA1
  • HA1
  • Ha-1
  • hHa1
  • KRTHA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.92
virus perturbation
0.85
gene perturbation
0.59
disease perturbation
0.56
cell line
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.45   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.45   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (64)
1 – 10 of 64
KRT82
Tdark
Novelty:  0.5488139
Score:  0.925
Data Source:  STRINGDB
KRT84
Tdark
Novelty:  0.23563823
Score:  0.923
Data Source:  STRINGDB
KRT2
Tbio
Novelty:  0.01448252
Score:  0.922
Data Source:  STRINGDB
KRT86
Tbio
Novelty:  0.01021995
Score:  0.922
Data Source:  STRINGDB
KRT77
Tbio
Novelty:  0.01331186
Score:  0.922
Data Source:  STRINGDB
KRT5
Tbio
Novelty:  0.00072336
Score:  0.921
Data Source:  STRINGDB
KRT85
Tbio
Novelty:  0.09341199
Score:  0.921
Data Source:  STRINGDB
KRT71
Tbio
Novelty:  0.06565294
Score:  0.92
Data Source:  STRINGDB
KRT81
Tbio
Novelty:  0.05514238
Score:  0.919
Data Source:  STRINGDB
KRT72
Tbio
Novelty:  0.06391566
Score:  0.918
Data Source:  STRINGDB
Pathways (4)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
49.5
hair color
2
2
0
1.2
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
49.5
hair color
0
1.2
48.5
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
keratin 31
VGNC:50416
454661
Macaque
keratin, type I cuticular Ha1
706173
Mouse
MGI:1309993
16660
Rat
RGD:1359411
450228
Horse
keratin 33A
100066898
Species
Name
OMA
EggNOG
Inparanoid
Chimp
keratin 31
Macaque
keratin, type I cuticular Ha1
Mouse
Rat
Horse
keratin 33A
Publication Statistics
PubMed Score 39.45
PubMed score by year
PubTator Score 34.56
PubTator score by year