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Tbio
POU4F3
POU domain, class 4, transcription factor 3

Protein Summary
Description
Acts as a transcriptional activator (PubMed:18228599). Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes (PubMed:18228599). Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear (By similarity). This gene encodes a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. This protein is found in the retina and may play a role in determining or maintaining the identities of a small subset of visual system neurons. Defects in this gene are the cause of non-syndromic sensorineural deafness autosomal dominant type 15. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000230732
  • ENSP00000230732
  • ENSG00000091010
  • ENST00000646991
  • ENSP00000495718

Symbol
  • BRN3C
  • BRN3C
  • DFNA15
  • DFNA42
  • DFNA52
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
protein domain
0.85
molecular function
0.76
PubMedID
0.67
biological process
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.17   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 233   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.17   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
1
2
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
42.3
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
POU class 4 homeobox 3
VGNC:4132
471685
Mouse
MGI:102523
18998
Rat
RGD:1310459
364855
Dog
POU class 4 homeobox 3
VGNC:44832
487200
Horse
POU class 4 homeobox 3
VGNC:21712
100071960
Species
Name
OMA
EggNOG
Inparanoid
Chimp
POU class 4 homeobox 3
Mouse
Rat
Dog
POU class 4 homeobox 3
Horse
POU class 4 homeobox 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q15319-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (18)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (67)
1 – 10 of 67
ATOH1
Tbio
Family:  TF
Novelty:  0.00397582
Score:  0.867
Data Source:  STRINGDB
GFI1
Tbio
Family:  TF
Novelty:  0.00466154
Score:  0.801
Data Source:  STRINGDB
ATOH7
Tbio
Family:  TF
Novelty:  0.00536814
Score:  0.768
Data Source:  STRINGDB
ISL1
Tbio
Family:  TF
Novelty:  0.00169431
Score:  0.759
Data Source:  STRINGDB
MYO7A
Tbio
Novelty:  0.00314435
Score:  0.713
Data Source:  STRINGDB
BARHL1
Tbio
Family:  TF
Novelty:  0.05894471
Score:  0.686
Data Source:  STRINGDB
GAP43
Tbio
Novelty:  0.00091023
Score:  0.683
Data Source:  STRINGDB
SOX2
Tbio
Family:  TF
Novelty:  0.00037089
Score:  0.64
Data Source:  STRINGDB
ESPN
Tbio
Novelty:  0.0035928
Score:  0.615
Data Source:  STRINGDB
LHX3
Tbio
Family:  TF
Novelty:  0.00784158
Score:  0.595
Data Source:  STRINGDB
Publication Statistics
PubMed Score  91.17

PubMed score by year
PubTator Score  41.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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