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Tbio
RALBP1
RalA-binding protein 1

Protein Summary
Description
Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin. RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive to the active state through the action of RALGDS (MIM 601619), which in turn is activated by RAS (see HRAS; MIM 190020) ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000019317
  • ENSP00000019317
  • ENSG00000017797
  • ENST00000383432
  • ENSP00000372924

Symbol
  • RLIP1
  • RLIP76
  • RIP1
  • RLIP1
  • RLIP76
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.98
transcription factor binding site profile
0.89
histone modification site profile
0.88
gene perturbation
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.17   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 450   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.17   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 450   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
1
1
1
43.7
low density lipoprotein cholesterol measurement
1
1
1
26.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
1
43.7
low density lipoprotein cholesterol measurement
1
26.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ralA binding protein 1
VGNC:7329
455292
Mouse
MGI:108466
19765
Rat
RGD:621134
84014
Dog
ralA binding protein 1
VGNC:45332
490548
Horse
ralA binding protein 1
VGNC:22161
100049994
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ralA binding protein 1
Mouse
Rat
Dog
ralA binding protein 1
Horse
ralA binding protein 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15311-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (27)
Rho GTPase cycle (R-HSA-194840)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Gene Ontology Terms (18)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (120)
1 – 10 of 120
REPS1
Tbio
Novelty: 0.08952347
p_int: 0.99999991
p_ni: 9.1e-8
Score: 0.974
Data Source: BioPlex,STRINGDB
MSANTD4
Tdark
Novelty: 0.09434234
p_int: 0.999999854
p_ni: 1e-9
p_wrong: 1.46e-7
Score: 0.214
Data Source: BioPlex,STRINGDB
REPS2
Tbio
Novelty: 0.0741316
p_int: 0.999999842
p_ni: 9e-9
p_wrong: 1.49e-7
Score: 0.975
Data Source: BioPlex,STRINGDB
KIFC1
Tchem
Novelty: 0.00982095
p_int: 0.999999836
p_ni: 1.35e-7
p_wrong: 2.9e-8
Score: 0.183
Data Source: BioPlex,STRINGDB
AP2M1
Tbio
Novelty: 0.00769368
p_int: 0.999999747
p_ni: 2.53e-7
Score: 0.815
Data Source: BioPlex,STRINGDB
SAPCD2
Tbio
Novelty: 0.06798955
p_int: 0.999999366
p_ni: 6.34e-7
Data Source: BioPlex
GPS2
Tbio
Novelty: 0.00986158
p_int: 0.999998747
p_ni: 4.33e-7
p_wrong: 8.21e-7
Score: 0.705
Data Source: BioPlex,STRINGDB
GOLGA4
Tbio
Novelty: 0.01363253
p_int: 0.999997386
p_ni: 0.000002614
Data Source: BioPlex
CCDC6
Tbio
Novelty: 0.00702098
p_int: 0.999996485
p_ni: 0.000003515
Data Source: BioPlex
PPP4R1
Tbio
Family: Enzyme
Novelty: 0.10822249
p_int: 0.99999452
p_ni: 0.00000548
Score: 0.377
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  92.17

PubMed score by year
PubTator Score  100.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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