Tbio RALBP1 RalA-binding protein 1

Protein Summary

Description

Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin. RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive to the active state through the action of RALGDS (MIM 601619), which in turn is activated by RAS (see HRAS; MIM 190020) (summary by Feig, 2003 [PubMed 12888294]).[supplied by OMIM, Nov 2010]

Uniprot Accession IDs

• Q15311
• D3DUI0
• RalBP1

Gene Name

• RALBP1

Ensembl ID

• ENST00000019317
• ENSP00000019317
• ENSG00000017797
• ENST00000383432
• ENSP00000372924

Symbol

• RLIP1
• RLIP76
• RIP1
• RLIP1
• RLIP76

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	0.98
transcription factor binding site profile	0.89
histone modification site profile	0.88
gene perturbation	0.86

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Rala-binding Protein 1

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Rala-binding Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.8   (req: < 5)

Gene RIFs: 56   (req: <= 3)

Antibodies: 450   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.8   (req: >= 5)

Gene RIFs: 56   (req: > 3)

Antibodies: 450   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0