Tbio IRF4 Interferon regulatory factor 4

Protein Summary

Description

Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity). The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]

Uniprot Accession IDs

• Q15306
• Q5VUI7
• Q99660
• IRF-4

Gene Name

• IRF4

Ensembl ID

• ENST00000380956
• ENSP00000370343
• ENSG00000137265

Symbol

• MUM1
• MUM1
• LSIRF
• SHEP8
• NF-EM5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
molecular function	0.96
trait	0.93
protein domain	0.85
disease	0.8

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Interferon Regulatory Factor 4

Protein / Nucleic Acid Binding / Interferon Regulatory Factor 4

Protein / ... / Winged Helix/forkhead Transcription Factor / Interferon Regulatory Factor 4

DTO Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Winged Helix/forkhead Transcription Factor / Interferon Regulatory Factor 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 684.27   (req: < 5)

Gene RIFs: 200   (req: <= 3)

Antibodies: 623   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 684.27   (req: >= 5)

Gene RIFs: 200   (req: > 3)

Antibodies: 623   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0