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Tbio
IRF4
Interferon regulatory factor 4

Protein Summary
Description
Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity). The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380956
  • ENSP00000370343
  • ENSG00000137265

Symbol
  • MUM1
  • MUM1
  • LSIRF
  • SHEP8
  • NF-EM5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
molecular function
0.96
trait
0.93
protein domain
0.85
disease
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 590.24   (req: < 5)
Gene RIFs: 136   (req: <= 3)
Antibodies: 623   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 590.24   (req: >= 5)
Gene RIFs: 136   (req: > 3)
Antibodies: 623   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (414)
BCL6
Tchem
Family:  TF
Novelty:  0.00066258
Score:  0.994
Data Source:  STRINGDB
STAT6
Tchem
Family:  TF
Novelty:  0.00096732
Score:  0.987
Data Source:  STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.985
Data Source:  STRINGDB
NFATC2
Tbio
Family:  TF
Novelty:  0.00312526
Score:  0.98
Data Source:  STRINGDB
NFATC1
Tchem
Family:  TF
Novelty:  0.00130337
Score:  0.965
Data Source:  STRINGDB
MAF
Tbio
Family:  TF
Novelty:  0.00040887
Score:  0.958
Data Source:  STRINGDB
CIITA
Tbio
Novelty:  0.00245662
Score:  0.953
Data Source:  STRINGDB
IFIT3
Tbio
Novelty:  0.00568113
Score:  0.949
Data Source:  STRINGDB
MX2
Tbio
Novelty:  0.00139073
Score:  0.946
Data Source:  STRINGDB
PRDM1
Tbio
Family:  TF; Epigenetic
Novelty:  0.00224931
Score:  0.943
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon alpha/beta signaling
Reactome
Interferon gamma signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon alpha/beta signaling
Interferon gamma signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (31)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (50)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
8
11
3
1.2
99.8
4
5
3
1.3
98.8
balding measurement
2
5
5
97.6
1
5
5
96.9
lymphocyte count
3
4
4
95.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
3
1.2
99.8
3
1.3
98.8
balding measurement
5
97.6
5
96.9
lymphocyte count
4
95.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interferon regulatory factor 4
VGNC:3128
462386
Macaque
interferon regulatory factor 4
722883
Mouse
MGI:1096873
16364
Rat
RGD:1308050
291100
Dog
interferon regulatory factor 4
VGNC:54316
100684399
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interferon regulatory factor 4
Macaque
interferon regulatory factor 4
Mouse
Rat
Dog
interferon regulatory factor 4
Publication Statistics
PubMed Score 590.24
PubMed score by year
PubTator Score 335.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Text