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Tclin
ERBB4
Receptor tyrosine-protein kinase erbB-4

Protein Summary
Description
Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alter ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342788
  • ENSP00000342235
  • ENSG00000178568
  • ENST00000436443
  • ENSP00000403204

Symbol
  • HER4
  • HER4
  • ALS19
  • p180erbB4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
ligand (protein)
1
molecular function
1
protein domain
1
trait
1


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 754.93   (req: < 5)
Gene RIFs: 225   (req: <= 3)
Antibodies: 1324   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 754.93   (req: >= 5)
Gene RIFs: 225   (req: > 3)
Antibodies: 1324   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 95
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 8
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
3
3
89.6
unipolar depression
2
4
5
79.3
urate measurement
2
2
2
77.6
body mass index
9
2
12
77.6
mathematical ability
2
2
2
76.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
89.6
unipolar depression
5
79.3
urate measurement
2
77.6
body mass index
12
77.6
mathematical ability
2
76.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
erb-b2 receptor tyrosine kinase 4
VGNC:372
459919
Macaque
erb-b2 receptor tyrosine kinase 4
693341
Mouse
MGI:104771
13869
Rat
RGD:620486
59323
Dog
erb-b2 receptor tyrosine kinase 4
VGNC:40437
488508
Species
Name
OMA
EggNOG
Inparanoid
Chimp
erb-b2 receptor tyrosine kinase 4
Macaque
erb-b2 receptor tyrosine kinase 4
Mouse
Rat
Dog
erb-b2 receptor tyrosine kinase 4
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15303-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (58)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 41
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
Gene Ontology Terms (66)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (266)
1 – 10 of 266
NRG1
Tbio
Novelty:  0.00095246
Score:  0.998
Data Source:  Reactome,STRINGDB
GRB2
Tchem
Novelty:  0.00091605
Score:  0.993
Data Source:  Reactome,STRINGDB
YAP1
Tchem
Novelty:  0.00124225
Score:  0.992
Data Source:  Reactome,STRINGDB
STAT5A
Tchem
Family:  TF
Novelty:  0.00074026
Score:  0.991
Data Source:  Reactome,STRINGDB
SHC1
Tchem
Novelty:  0.00083615
Score:  0.99
Data Source:  Reactome,STRINGDB
HBEGF
Tbio
Novelty:  0.00105355
Score:  0.989
Data Source:  Reactome,STRINGDB
NRG2
Tbio
Novelty:  0.01986994
Score:  0.989
Data Source:  Reactome,STRINGDB
NRG3
Tbio
Novelty:  0.01706672
Score:  0.987
Data Source:  STRINGDB
STAT5B
Tchem
Family:  TF
Novelty:  0.00074178
Score:  0.986
Data Source:  STRINGDB
DLG4
Tchem
Novelty:  0.00057285
Score:  0.985
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  754.93

PubMed score by year
PubTator Score  549.56

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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