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Tbio
RCN1
Reticulocalbin-1

Protein Summary
Description
May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. High conservation of amino acid residues outside of these motifs, in comparison to mouse reticulocalbin, is consistent with a possible biochemical function besides that of calcium binding. In human endothelial and prostate cancer cell lines this protein localizes to the plasma membrane.[provided by RefSeq, Jan 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000054950
  • ENSP00000054950
  • ENSG00000049449

Symbol
  • RCN
  • RCN
  • RCAL
  • PIG20
  • HEL-S-84
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
protein complex
0.97
PubMedID
0.92
transcription factor perturbation
0.91
disease perturbation
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.82   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 132   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.82   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
1
1
56
body mass index
1
1
1
40.7
basophil count
2
1
2
11.4
apolipoprotein B measurement
1
1
1
3.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
56
body mass index
1
40.7
basophil count
2
11.4
apolipoprotein B measurement
1
3.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:104559
19672
Rat
RGD:1311292
362182
Dog
reticulocalbin 1
VGNC:52039
475952
Horse
reticulocalbin 1
VGNC:22272
100072670
Cow
reticulocalbin 1
VGNC:33831
281445
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
reticulocalbin 1
Horse
reticulocalbin 1
Cow
reticulocalbin 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q15293-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Post-translational protein phosphorylation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (175)
1 – 10 of 175
PTRH1
Tdark
Family:  Enzyme
Novelty:  0.20240403
p_int:  0.999915315
p_ni:  7.2e-8
p_wrong:  0.000084613
Score:  0.54
Data Source:  BioPlex,STRINGDB
VWA1
Tbio
Novelty:  0.00212445
p_int:  0.999888719
p_ni:  0.00011128
Score:  0.92
Data Source:  BioPlex,STRINGDB
WDR45B
Tbio
Novelty:  0.22407227
p_int:  0.985832864
p_ni:  0.014167136
Score:  0.167
Data Source:  BioPlex,STRINGDB
SPECC1L
Tbio
Novelty:  0.06116909
p_int:  0.984472916
p_ni:  0.015527084
Score:  0.185
Data Source:  BioPlex,STRINGDB
RNF41
Tbio
Family:  Enzyme
Novelty:  0.01953473
p_int:  0.960503955
p_ni:  0.039494902
p_wrong:  0.000001143
Score:  0.196
Data Source:  BioPlex,STRINGDB
MYO18A
Tbio
Novelty:  0.05058328
p_int:  0.912969311
p_ni:  0.087030689
Score:  0.189
Data Source:  BioPlex,STRINGDB
HNRNPLL
Tbio
Novelty:  0.0498467
p_int:  0.876717151
p_ni:  0.016678649
p_wrong:  0.1066042
Score:  0.196
Data Source:  BioPlex,STRINGDB
PPP1R9A
Tbio
Novelty:  0.04851082
p_int:  0.875346518
p_ni:  0.123412137
p_wrong:  0.001241346
Score:  0.167
Data Source:  BioPlex,STRINGDB
P4HB
Tchem
Family:  Enzyme
Novelty:  0.00107905
Score:  0.985
Data Source:  STRINGDB
HSP90B1
Tchem
Novelty:  0.00135881
Score:  0.983
Data Source:  STRINGDB
Publication Statistics
PubMed Score  118.82

PubMed score by year
PubTator Score  195.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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