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Tbio
RBBP5
Retinoblastoma-binding protein 5

Protein Summary
Description
In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264515
  • ENSP00000264515
  • ENSG00000117222
  • ENST00000367164
  • ENSP00000356132

Symbol
  • RBQ3
  • RBQ3
  • SWD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.98
interacting protein
0.95
protein complex
0.93
histone modification site profile
0.83
ligand (protein) perturbation
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.08   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 251   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.08   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 251   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
86.3
sex hormone-binding globulin measurement
2
1
2
84.4
basophil percentage of granulocytes
1
1
1
32.9
triglyceride measurement
1
1
1
28.1
myeloid white cell count
1
1
1
7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
86.3
sex hormone-binding globulin measurement
2
84.4
basophil percentage of granulocytes
1
32.9
triglyceride measurement
1
28.1
myeloid white cell count
1
7
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RB binding protein 5, histone lysine methyltransferase complex subunit
VGNC:11832
457665
Macaque
RB binding protein 5, histone lysine methyltransferase complex subunit
699057
Mouse
MGI:1918367
213464
Rat
RGD:1305532
304794
Dog
RB binding protein 5, histone lysine methyltransferase complex subunit
VGNC:53127
488568
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RB binding protein 5, histone lysine methyltransferase complex subunit
Macaque
RB binding protein 5, histone lysine methyltransferase complex subunit
Mouse
Rat
Dog
RB binding protein 5, histone lysine methyltransferase complex subunit
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15291-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (20)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Deactivation of the beta-catenin transactivating complex
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Chromatin modifying enzymes
Chromatin organization
Deactivation of the beta-catenin transactivating complex
Protein-Protein Interactions (308)
1 – 10 of 308
WDR5
Tchem
Novelty: 0.0059945
p_int: 0.993041613
p_ni: 0.006958387
Score: 0.996
Data Source: BioPlex,STRINGDB
HCFC2
Tbio
Novelty: 0.12260416
p_int: 0.987856521
p_ni: 0.012143479
Score: 0.893
Data Source: BioPlex,STRINGDB
CXXC1
Tbio
Family: Epigenetic
Novelty: 0.01019251
p_int: 0.89813208
p_ni: 0.10186792
Score: 0.995
Data Source: BioPlex,STRINGDB
CSNK2B
Tbio
Family: Kinase
Novelty: 0.00152367
p_int: 0.850894011
p_ni: 0.149105989
Score: 0.157
Data Source: BioPlex,STRINGDB
RPL37A
Tbio
Novelty: 0.03475061
p_int: 0.774137203
p_ni: 0.225862797
Score: 0.165
Data Source: BioPlex,STRINGDB
ASH2L
Tbio
Family: Enzyme
Novelty: 0.01586766
Score: 0.999
Data Source: STRINGDB
SETD1B
Tbio
Family: Epigenetic
Novelty: 0.03331663
Score: 0.999
Data Source: STRINGDB
DPY30
Tbio
Novelty: 0.03098629
Score: 0.998
Data Source: STRINGDB
SETD1A
Tbio
Family: Epigenetic
Novelty: 0.00248544
Score: 0.998
Data Source: STRINGDB
WDR82
Tbio
Novelty: 0.04679153
Score: 0.998
Data Source: STRINGDB
Publication Statistics
PubMed Score  36.08

PubMed score by year
PubTator Score  19.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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