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Tbio
RNPS1
RNA-binding protein with serine-rich domain 1

Protein Summary
Description
Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in d ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301730
  • ENSP00000301730
  • ENSG00000205937
  • ENST00000320225
  • ENSP00000315859
  • ENST00000397086
  • ENSP00000380275
  • ENST00000565678
  • ENSP00000457723
  • ENST00000566458
  • ENSP00000456352
  • ENST00000568631
  • ENSP00000457820

Symbol
  • LDC2
  • E5.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.97
kinase perturbation
0.96
histone modification site profile
0.85
interacting protein
0.85
transcription factor binding site profile
0.84


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.02   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.02   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA binding protein with serine rich domain 1
VGNC:9391
750086
Macaque
RNA binding protein with serine rich domain 1
695816
Mouse
MGI:97960
19826
Rat
RGD:1307522
287113
Dog
RNA binding protein with serine rich domain 1
VGNC:45683
479880
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA binding protein with serine rich domain 1
Macaque
RNA binding protein with serine rich domain 1
Mouse
Rat
Dog
RNA binding protein with serine rich domain 1
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (19)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Gene expression (Transcription)
Metabolism of RNA
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Gene Ontology Terms (18)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (411)
1 – 10 of 411
EPB41L2
Tbio
Novelty: 0.0311733
p_int: 0.999992959
p_ni: 0.000007041
Score: 0.307
Data Source: BioPlex,STRINGDB
EPB41L3
Tbio
Novelty: 0.00915217
p_int: 0.999992622
p_ni: 0.000007378
Data Source: BioPlex
SAP18
Tbio
Family: Enzyme
Novelty: 0.03918373
p_int: 0.999979229
p_ni: 0.000020771
Score: 0.997
Data Source: BioPlex,STRINGDB
EPB41L1
Tbio
Novelty: 0.02937451
p_int: 0.999979069
p_ni: 0.000020931
Data Source: BioPlex
SNIP1
Tbio
Novelty: 0.01865867
p_int: 0.99993574
p_ni: 0.00006426
Score: 0.304
Data Source: BioPlex,STRINGDB
CAMKV
Tbio
Family: Kinase
Novelty: 0.17794181
p_int: 0.999935389
p_ni: 0.000064611
Score: 0.184
Data Source: BioPlex,STRINGDB
PIP4K2A
Tbio
Family: Kinase
Novelty: 0.01130885
p_int: 0.999910131
p_ni: 0.000089869
Data Source: BioPlex
PNN
Tbio
Novelty: 0.01395394
p_int: 0.9997542
p_ni: 0.0002458
Score: 0.989
Data Source: BioPlex,STRINGDB
LUC7L2
Tdark
Novelty: 0.36989457
p_int: 0.999667499
p_ni: 0.000332501
Score: 0.198
Data Source: BioPlex,STRINGDB
NKAPD1
Tdark
Novelty: 1.56979675
p_int: 0.999494101
p_ni: 0.000505899
Data Source: BioPlex
Publication Statistics
PubMed Score  31.02

PubMed score by year
PubTator Score  58.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer