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Tbio
RAB35
Ras-related protein Rab-35

Protein Summary
Description
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. May indirectly regulate neurite outgrowth. Together with TBC1D13 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229340
  • ENSP00000229340
  • ENSG00000111737
  • ENST00000534951
  • ENSP00000441883

Symbol
  • RAB1C
  • RAY
  • RAY
  • H-ray
  • RAB1C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
molecular function
0.98
cellular component
0.9
kinase perturbation
0.81
disease perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.34   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 290   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.34   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 290   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
20.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
20.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB35, member RAS oncogene family
VGNC:13354
104001711
Mouse
MGI:1924657
77407
Rat
RGD:1306362
288700
Dog
RAB35, member RAS oncogene family
VGNC:45278
611477
Horse
RAB35, member RAS oncogene family
VGNC:22111
100053915
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB35, member RAS oncogene family
Mouse
Rat
Dog
RAB35, member RAS oncogene family
Horse
RAB35, member RAS oncogene family
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (9)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
RAB GEFs exchange GTP for GDP on RABs
Reactome
RAB geranylgeranylation
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
Metabolism of proteins
Post-translational protein modification
RAB GEFs exchange GTP for GDP on RABs
RAB geranylgeranylation
Protein-Protein Interactions (147)
1 – 10 of 147
GDI1
Tbio
Novelty: 0.01710945
p_int: 0.999449319
p_ni: 0.000550681
Score: 0.962
Data Source: BioPlex,Reactome,STRINGDB
DENND1A
Tbio
Novelty: 0.04823149
Score: 0.99
Data Source: Reactome,STRINGDB
DENND1B
Tbio
Novelty: 0.07206972
Score: 0.988
Data Source: Reactome,STRINGDB
DENND1C
Tbio
Novelty: 0.82231203
Score: 0.988
Data Source: Reactome,STRINGDB
TBC1D10A
Tbio
Novelty: 0.16930827
Score: 0.986
Data Source: STRINGDB
TBC1D10B
Tbio
Novelty: 0.37152309
Score: 0.976
Data Source: STRINGDB
RAB3C
Tbio
Family: Enzyme
Novelty: 0.06291754
Score: 0.974
Data Source: STRINGDB
TBC1D24
Tbio
Novelty: 0.0161631
Score: 0.974
Data Source: STRINGDB
RAB3A
Tbio
Family: Enzyme
Novelty: 0.0043532
Score: 0.974
Data Source: STRINGDB
RAB3B
Tbio
Family: Enzyme
Novelty: 0.02731183
Score: 0.974
Data Source: STRINGDB
Publication Statistics
PubMed Score  73.34

PubMed score by year
PubTator Score  35.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer