Tbio RABEP1 Rab GTPase-binding effector protein 1

Protein Summary

Description

Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane (PubMed:22841712). Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium (By similarity).

Uniprot Accession IDs

• Q15276
• B2RAG7
• O95369
• Q8IVX3

Gene Name

• RABEP1

Ensembl ID

• ENST00000341923
• ENSP00000339569
• ENSG00000029725
• ENST00000537505
• ENSP00000445408

Symbol

• RAB5EP
• RABPT5
• RABPT5A
• RAB5EP
• RABPT5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.87
transcription factor perturbation	0.84
interacting protein	0.8
drug perturbation	0.71
kinase perturbation	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.72   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 102   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.72   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0