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Tbio
RABEP1
Rab GTPase-binding effector protein 1

Protein Summary
Description
Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane (PubMed:22841712). Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341923
  • ENSP00000339569
  • ENSG00000029725
  • ENST00000537505
  • ENSP00000445408

Symbol
  • RAB5EP
  • RABPT5
  • RABPT5A
  • RAB5EP
  • RABPT5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
transcription factor perturbation
0.84
interacting protein
0.8
drug perturbation
0.71
kinase perturbation
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.71   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.71   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
7
2
8
96.5
1
1
0
1.1
40.8
mean platelet volume
1
1
1
31
monocyte count
1
1
1
15.1
lymphocyte count
1
1
1
15.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
8
96.5
0
1.1
40.8
mean platelet volume
1
31
monocyte count
1
15.1
lymphocyte count
1
15.1
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1860236
54189
Rat
RGD:708568
54190
Dog
rabaptin, RAB GTPase binding effector protein 1
VGNC:45300
489451
Horse
rabaptin, RAB GTPase binding effector protein 1
VGNC:22133
100072805
Cow
rabaptin, RAB GTPase binding effector protein 1
VGNC:33667
504785
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
rabaptin, RAB GTPase binding effector protein 1
Horse
rabaptin, RAB GTPase binding effector protein 1
Cow
rabaptin, RAB GTPase binding effector protein 1
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
Rab regulation of trafficking
Reactome
TBC/RABGAPs
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
Rab regulation of trafficking
TBC/RABGAPs
Vesicle-mediated transport
Protein-Protein Interactions (122)
1 – 10 of 122
CLIP1
Tbio
Novelty: 0.00399891
p_int: 0.999999997
p_ni: 3e-9
Data Source: BioPlex
RABGEF1
Tbio
Novelty: 0.02830695
p_int: 0.99999999
p_ni: 1.1e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CCDC186
Tdark
Novelty: 0.44973807
p_int: 0.999985532
p_ni: 0.0000143
p_wrong: 1.67e-7
Data Source: BioPlex
CCDC183
Tdark
Novelty: 1.55719016
p_int: 0.999916195
p_ni: 0.000083803
p_wrong: 2e-9
Score: 0.313
Data Source: BioPlex,STRINGDB
SLMAP
Tbio
Novelty: 0.03974856
p_int: 0.999908841
p_ni: 0.000091159
Score: 0.152
Data Source: BioPlex,STRINGDB
TMEM266
Tdark
Novelty: 0.26313861
p_int: 0.999834171
p_ni: 0.000165829
Score: 0.188
Data Source: BioPlex,STRINGDB
VPS52
Tbio
Novelty: 0.01439614
p_int: 0.999824955
p_ni: 0.000175045
Data Source: BioPlex
KIF20A
Tchem
Novelty: 0.01640924
p_int: 0.999289039
p_ni: 0.000710358
p_wrong: 6.03e-7
Data Source: BioPlex
CENPE
Tchem
Novelty: 0.00458125
p_int: 0.998769463
p_ni: 0.001230536
p_wrong: 1e-9
Data Source: BioPlex
GGA2
Tbio
Novelty: 0.01750948
p_int: 0.996114963
p_ni: 0.003885034
p_wrong: 3e-9
Score: 0.979
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  39.71

PubMed score by year
PubTator Score  37.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer