Tbio QPRT Nicotinate-nucleotide pyrophosphorylase [carboxylating]

Protein Summary

Description

Involved in the catabolism of quinolinic acid (QA). This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• Q15274
• Q53XW7
• Q96G22
• Q9BSG6

Gene Name

• QPRT

Ensembl ID

• ENST00000395384
• ENSP00000378782
• ENSG00000103485

Symbol

• QPRTase
• HEL-S-90n

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.84
PubMedID	0.77
protein domain	0.73
gene perturbation	0.71
disease perturbation	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 146.96   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 283   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 146.96   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 283   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0