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Tbio
QPRT
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

Protein Summary
Description
Involved in the catabolism of quinolinic acid (QA). This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395384
  • ENSP00000378782
  • ENSG00000103485

Symbol
  • QPRTase
  • HEL-S-90n
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
PubMedID
0.77
protein domain
0.73
gene perturbation
0.71
disease perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.8   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 283   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.8   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 283   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (19)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Nicotinate metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Nicotinate metabolism
Protein-Protein Interactions (91)
1 – 10 of 91
RAVER2
Tbio
Novelty: 0.35773243
p_int: 0.999999217
p_ni: 7.77e-7
p_wrong: 6e-9
Score: 0.212
Data Source: BioPlex,STRINGDB
SATB2
Tbio
Family: TF
Novelty: 0.00405935
p_int: 0.999989946
p_ni: 0.000010054
Data Source: BioPlex
SATB1
Tbio
Family: TF
Novelty: 0.00434577
p_int: 0.999986087
p_ni: 0.000009813
p_wrong: 0.0000041
Score: 0.212
Data Source: BioPlex,STRINGDB
TRAF3IP2
Tbio
Novelty: 0.02270581
p_int: 0.999964553
p_ni: 9.03e-7
p_wrong: 0.000034544
Score: 0.345
Data Source: BioPlex,STRINGDB
NPL
Tbio
Family: Enzyme
Novelty: 0.00944797
p_int: 0.99996304
p_ni: 0.000035757
p_wrong: 0.000001203
Score: 0.432
Data Source: BioPlex,STRINGDB
TRIM33
Tbio
Family: Epigenetic
Novelty: 0.00415877
p_int: 0.999959006
p_ni: 0.000040994
Data Source: BioPlex
IRF2BP1
Tdark
Novelty: 0.29719488
p_int: 0.999872382
p_ni: 0.00012689
p_wrong: 7.27e-7
Data Source: BioPlex
PATL1
Tbio
Novelty: 0.10847
p_int: 0.999807741
p_ni: 0.000192259
Score: 0.212
Data Source: BioPlex,STRINGDB
CRY2
Tbio
Novelty: 0.00156961
p_int: 0.999258559
p_ni: 0.00074081
p_wrong: 6.31e-7
Score: 0.305
Data Source: BioPlex,STRINGDB
PER1
Tbio
Novelty: 0.01290576
p_int: 0.998886763
p_ni: 0.001113237
Score: 0.194
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  127.80

PubMed score by year
PubTator Score  27.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer