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Tbio
PWP2
Periodic tryptophan protein 2 homolog

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291576
  • ENSP00000291576
  • ENSG00000241945

Symbol
  • PWP2H
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.94
protein complex
0.75
tissue sample
0.68
cellular component
0.66
histone modification site profile
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.68   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 135   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.68   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (324)
MPHOSPH6
Tbio
Family:  Enzyme
Novelty:  0.24387167
p_int:  0.999968047
p_ni:  0.000031953
Score:  0.904
Data Source:  BioPlex,STRINGDB
WDR36
Tbio
Novelty:  0.02010676
p_int:  0.999940188
p_ni:  0.000059812
Score:  0.999
Data Source:  BioPlex,STRINGDB
TMEM206
Tdark
Novelty:  0.17311172
p_int:  0.999061264
p_ni:  0.000938736
Data Source:  BioPlex
TGFA
Tbio
Novelty:  0.00216159
p_int:  0.997246647
p_ni:  0.002753353
Data Source:  BioPlex
GYPB
Tbio
Novelty:  0.00442195
p_int:  0.996157494
p_ni:  0.003842343
p_wrong:  1.63e-7
Data Source:  BioPlex
FGF8
Tbio
Novelty:  0.00155113
p_int:  0.957919522
p_ni:  0.042080457
p_wrong:  2.1e-8
Data Source:  BioPlex
FGF3
Tbio
Novelty:  0.00474087
p_int:  0.957411967
p_ni:  0.040513352
p_wrong:  0.002074682
Data Source:  BioPlex
MECP2
Tchem
Family:  TF
Novelty:  0.00051767
p_int:  0.948175265
p_ni:  0.05182455
p_wrong:  1.85e-7
Data Source:  BioPlex
ZNF71
Tbio
Family:  TF
Novelty:  0.24703192
p_int:  0.940215014
p_ni:  0.054463181
p_wrong:  0.005321806
Data Source:  BioPlex
DNAJC7
Tbio
Novelty:  0.02133191
p_int:  0.939155637
p_ni:  0.060844346
p_wrong:  1.6e-8
Score:  0.164
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.1
90.1
1
1
0
1.1
77.7
2
2
0
1.1
76.2
1
1
0
1.1
33.1
1
1
0
1.1
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
90.1
0
1.1
77.7
0
1.1
76.2
0
1.1
33.1
0
1.1
28.1
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
PWP2, small subunit processome component
722216
Mouse
MGI:1341200
110816
Rat
RGD:1582817
690297
Dog
PWP2, small subunit processome component
487790
Horse
PWP2, small subunit processome component
102149423
Species
Name
OMA
EggNOG
Inparanoid
Macaque
PWP2, small subunit processome component
Mouse
Rat
Dog
PWP2, small subunit processome component
Horse
PWP2, small subunit processome component
Publication Statistics
PubMed Score 18.68
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title