Tbio PTPRK Receptor-type tyrosine-protein phosphatase kappa

Protein Summary

Description

Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q15262
• B2RTQ8
• B7ZMG0
• Q14763
• Q5TG10
• Q5TG11
• Protein-tyrosine phosphatase kappa

Gene Name

• PTPRK

Ensembl ID

• ENST00000368213
• ENSP00000357196
• ENSG00000152894
• ENST00000368215
• ENSP00000357198
• ENST00000368226
• ENSP00000357209
• ENST00000532331
• ENSP00000432973
• ENST00000618215
• ENSP00000484742
• ENSG00000273993
• ENST00000618924
• ENSP00000483766
• ENST00000619256
• ENSP00000477791
• ENST00000628183
• ENSP00000486442

Symbol

• PTPK
• R-PTP-kappa

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
trait	0.97
transcription factor perturbation	0.94
biological process	0.82
disease perturbation	0.79

Protein Classes

PANTHER Classes

Protein / Receptor / Receptor-type Tyrosine-protein Phosphatase Kappa

Protein / Hydrolase / Phosphatase / Protein Phosphatase / Receptor-type Tyrosine-protein Phosphatase Kappa

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Protein Phosphatase / Receptor-type Tyrosine-protein Phosphatase Kappa

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.23   (req: < 5)

Gene RIFs: 26   (req: <= 3)

Antibodies: 46   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.23   (req: >= 5)

Gene RIFs: 26   (req: > 3)

Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (131)

Explore Interacting Targets

1 – 10 of 131

• See Interactions on String-DB

RPL28

Tbio

Novelty:  0.03136035

p_int:  0.999992331

p_ni:  0.000007669

Data Source:  BioPlex

COL6A2

Tbio

Novelty:  0.01275082

p_int:  0.999704147

p_ni:  0.000295853

Data Source:  BioPlex

PTPRU

Tbio

Family:  Enzyme

Novelty:  0.0090218

p_int:  0.999688206

p_ni:  0.000311793

Score:  0.197

Data Source:  BioPlex,STRINGDB

LGALS9

Tchem

Novelty:  0.00381766

p_int:  0.999587925

p_ni:  0.000412074

p_wrong:  1e-9

Data Source:  BioPlex

EOGT

Tbio

Family:  Enzyme

Novelty:  0.08290891

p_int:  0.999583725

p_ni:  0.000416195

p_wrong:  8e-8

Data Source:  BioPlex

ARSB

Tbio

Family:  Enzyme

Novelty:  0.01044355

p_int:  0.999390122

p_ni:  0.000602194

p_wrong:  0.000007684

Score:  0.161

Data Source:  BioPlex,STRINGDB

CTSF

Tchem

Family:  Enzyme

Novelty:  0.01359417

p_int:  0.99929655

p_ni:  0.000703449

p_wrong:  1e-9

Data Source:  BioPlex

FUT11

Tbio

Family:  Enzyme

Novelty:  0.16098097

p_int:  0.998976002

p_ni:  0.001023997

Data Source:  BioPlex

EVA1B

Tdark

Novelty:  2.1380272

p_int:  0.99890186

p_ni:  0.00109814

Data Source:  BioPlex

SUSD1

Tdark

Novelty:  0.54249826

p_int:  0.998359209

p_ni:  0.001640754

p_wrong:  3.7e-8

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (6)

Reactome (4)

PathwayCommons (2)

EGFR downregulation (R-HSA-182971)

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1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	EGFR downregulation	31 targets	R-HSA-182971
Reactome	Signal Transduction	2704 targets	R-HSA-162582
Reactome	Signaling by EGFR	49 targets	R-HSA-177929
Reactome	Signaling by Receptor Tyrosine Kinases	455 targets	R-HSA-9006934

Name	Explore in Pharos	Explore in Source
EGFR downregulation	31 targets	R-HSA-182971
Signal Transduction	2704 targets	R-HSA-162582
Signaling by EGFR	49 targets	R-HSA-177929
Signaling by Receptor Tyrosine Kinases	455 targets	R-HSA-9006934

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (33)

Functions (5)

Components (13)

Processes (15)

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1 – 5 of 5

GO Term	Evidence	Assigned by
protein tyrosine phosphatase activity	Inferred from Direct Assay (IDA)	UniProtKB
beta-catenin binding	Inferred from Physical Interaction (IPI)	UniProtKB
gamma-catenin binding	Inferred from Physical Interaction (IPI)	UniProtKB
protein kinase binding	Inferred from Physical Interaction (IPI)	UniProtKB
transmembrane receptor protein tyrosine phosphatase activity	Non-traceable Author Statement (NAS)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (34)

Items per page:

5

1 – 5 of 34

GWAS Trait	EFO ID	ENSG ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
asthma	EFO_0000270	ENSG00000152894	5	5	0	1.1	87
asthma	EFO_0000270	ENSG00000273993	5	5	0	1.1	87
celiac disease	EFO_0001060	ENSG00000152894	3	3	0	1.2	85.6
celiac disease	EFO_0001060	ENSG00000273993	3	3	0	1.2	85.6
childhood onset asthma	EFO_0004591	ENSG00000152894	1	1	0	1.1	64.4

Items per page:

5

1 – 5 of 34

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
asthma	EFO_0000270	0	1.1	87
asthma	EFO_0000270	0	1.1	87
celiac disease	EFO_0001060	0	1.2	85.6
celiac disease	EFO_0001060	0	1.2	85.6
childhood onset asthma	EFO_0004591	0	1.1	64.4

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Cell junction
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Hydrolase
Immunoglobulin domain
Membrane

GWAS Trait Find Similar Targets

No Header	No Header
age at menarche
allergic rhinitis
allergy
asthma
celiac disease
childhood onset asthma
chronic lymphocytic leukemia
Crohn's disease
Eczema
generalised epilepsy

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
vision/eye phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	protein tyrosine phosphatase, receptor type K	VGNC:11196	745734
Mouse	protein tyrosine phosphatase, receptor type, K	MGI:103310	19272
Rat	protein tyrosine phosphatase, receptor type, K	RGD:619706	360302
Dog	protein tyrosine phosphatase, receptor type K	VGNC:45191	476290
Horse	protein tyrosine phosphatase, receptor type K	VGNC:22034	100073063

Species	Name	OMA	EggNOG	Inparanoid
Chimp	protein tyrosine phosphatase, receptor type K
Mouse	protein tyrosine phosphatase, receptor type, K
Rat	protein tyrosine phosphatase, receptor type, K
Dog	protein tyrosine phosphatase, receptor type K
Horse	protein tyrosine phosphatase, receptor type K

Publication Statistics

PubMed Score 39.23

PubMed score by year

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PubTator Score 30.21

PubTator score by year

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Related Publications

Text Mined References (44)

GeneRif Annotations (26)

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0 of 0

PMID	Year	Title