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Tbio
PTPRK
Receptor-type tyrosine-protein phosphatase kappa

Protein Summary
Description
Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adheren ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368213
  • ENSP00000357196
  • ENSG00000152894
  • ENST00000368215
  • ENSP00000357198
  • ENST00000368226
  • ENSP00000357209
  • ENST00000532331
  • ENSP00000432973
  • ENST00000618215
  • ENSP00000484742
  • ENSG00000273993
  • ENST00000618924
  • ENSP00000483766
  • ENST00000619256
  • ENSP00000477791
  • ENST00000628183
  • ENSP00000486442

Symbol
  • PTPK
  • R-PTP-kappa
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
trait
0.97
transcription factor perturbation
0.94
biological process
0.82
disease perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.23   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.23   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (131)
RPL28
Tbio
Novelty:  0.03136035
p_int:  0.999992331
p_ni:  0.000007669
Data Source:  BioPlex
COL6A2
Tbio
Novelty:  0.01275082
p_int:  0.999704147
p_ni:  0.000295853
Data Source:  BioPlex
PTPRU
Tbio
Family:  Enzyme
Novelty:  0.0090218
p_int:  0.999688206
p_ni:  0.000311793
Score:  0.197
Data Source:  BioPlex,STRINGDB
LGALS9
Tchem
Novelty:  0.00381766
p_int:  0.999587925
p_ni:  0.000412074
p_wrong:  1e-9
Data Source:  BioPlex
EOGT
Tbio
Family:  Enzyme
Novelty:  0.08290891
p_int:  0.999583725
p_ni:  0.000416195
p_wrong:  8e-8
Data Source:  BioPlex
ARSB
Tbio
Family:  Enzyme
Novelty:  0.01044355
p_int:  0.999390122
p_ni:  0.000602194
p_wrong:  0.000007684
Score:  0.161
Data Source:  BioPlex,STRINGDB
CTSF
Tchem
Family:  Enzyme
Novelty:  0.01359417
p_int:  0.99929655
p_ni:  0.000703449
p_wrong:  1e-9
Data Source:  BioPlex
FUT11
Tbio
Family:  Enzyme
Novelty:  0.16098097
p_int:  0.998976002
p_ni:  0.001023997
Data Source:  BioPlex
EVA1B
Tdark
Novelty:  2.1380272
p_int:  0.99890186
p_ni:  0.00109814
Data Source:  BioPlex
SUSD1
Tdark
Novelty:  0.54249826
p_int:  0.998359209
p_ni:  0.001640754
p_wrong:  3.7e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
EGFR downregulation (R-HSA-182971)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
EGFR downregulation
Reactome
Signal Transduction
Reactome
Signaling by EGFR
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
EGFR downregulation
Signal Transduction
Signaling by EGFR
Signaling by Receptor Tyrosine Kinases
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (33)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (34)
Items per page:
1 – 5 of 34
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
5
0
1.1
87
5
5
0
1.1
87
3
3
0
1.2
85.6
3
3
0
1.2
85.6
childhood onset asthma
1
1
0
1.1
64.4
Items per page:
1 – 5 of 34
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
87
0
1.1
87
0
1.2
85.6
0
1.2
85.6
childhood onset asthma
0
1.1
64.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, receptor type K
VGNC:11196
745734
Mouse
MGI:103310
19272
Rat
RGD:619706
360302
Dog
protein tyrosine phosphatase, receptor type K
VGNC:45191
476290
Horse
protein tyrosine phosphatase, receptor type K
VGNC:22034
100073063
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, receptor type K
Mouse
Rat
Dog
protein tyrosine phosphatase, receptor type K
Horse
protein tyrosine phosphatase, receptor type K
Publication Statistics
PubMed Score 39.23
PubMed score by year
PubTator Score 30.21
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title