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Tchem
PTPA
Serine/threonine-protein phosphatase 2A activator

Protein Summary
Description
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337738
  • ENSP00000337448
  • ENSG00000119383
  • ENST00000355007
  • ENSP00000347109
  • ENST00000357197
  • ENSP00000349726
  • ENST00000358994
  • ENSP00000351885
  • ENST00000393370
  • ENSP00000377036

Symbol
  • PPP2R4
  • PP2A
  • PR53
  • PPP2R4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2038.41   (req: < 5)
Gene RIFs: 103   (req: <= 3)
Antibodies: 340   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2038.41   (req: >= 5)
Gene RIFs: 103   (req: > 3)
Antibodies: 340   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL40248
chemical structure image
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
3
3
3
89.7
red blood cell distribution width
2
2
2
84.9
urinary metabolite measurement
1
1
1
68.8
1
1
1
68.8
hypersomnia
1
1
0
2.6
38.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
3
89.7
red blood cell distribution width
2
84.9
urinary metabolite measurement
1
68.8
1
68.8
hypersomnia
0
2.6
38.9
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (21)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
HGNC
Protein-Protein Interactions (270)
1 – 10 of 270
PPP4R2
Tbio
Family: Enzyme
Novelty: 0.15136638
p_int: 0.9999949
p_ni: 0.0000051
Score: 0.969
Data Source: BioPlex,STRINGDB
PPP4R3A
Tbio
Family: Enzyme
Novelty: 0.04234592
p_int: 0.863276069
p_ni: 0.136723931
Score: 0.921
Data Source: BioPlex,STRINGDB
PPP2CA
Tchem
Family: Enzyme
Novelty: 0.00496839
Score: 0.999
Data Source: STRINGDB
PPP2R1A
Tbio
Family: Enzyme
Novelty: 0.01134139
Score: 0.999
Data Source: STRINGDB
PPP2R1B
Tbio
Family: Enzyme
Novelty: 0.03936638
Score: 0.984
Data Source: STRINGDB
PPP4C
Tbio
Family: Enzyme
Novelty: 0.00705824
Score: 0.974
Data Source: STRINGDB
SGO1
Tbio
Novelty: 0.01115849
Score: 0.97
Data Source: STRINGDB
MDM2
Tchem
Family: Enzyme
Novelty: 0.00028385
Score: 0.961
Data Source: STRINGDB
PPP2CB
Tbio
Family: Enzyme
Novelty: 0.0483178
Score: 0.955
Data Source: STRINGDB
PPP2R5A
Tchem
Family: Enzyme
Novelty: 0.03073487
Score: 0.953
Data Source: STRINGDB
Publication Statistics
PubMed Score  2038.41

PubMed score by year
PubTator Score  1316.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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