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Tbio
PTPRR
Receptor-type tyrosine-protein phosphatase R

Protein Summary
Description
Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity). The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, recep ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000283228
  • ENSP00000283228
  • ENSG00000153233
  • ENST00000342084
  • ENSP00000339605
  • ENST00000378778
  • ENSP00000368054
  • ENST00000440835
  • ENSP00000391750
  • ENST00000549308
  • ENSP00000446943

Symbol
  • ECPTP
  • PTPRQ
  • PTPRQ
  • EC-PTP
  • PCPTP1
  • PTP-SL
  • PTPBR7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
molecular function
0.7
gene perturbation
0.69
transcription factor
0.69
disease
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.74   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 263   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.74   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 263   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
2
3
2
7.4
93.1
influenza A (H1N1)
2
1
0
31.8
68.7
age at onset
1
1
0
7.4
46.7
Myopia
1
1
0
7.4
46.7
Abnormality of refraction
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
2
7.4
93.1
influenza A (H1N1)
0
31.8
68.7
age at onset
0
7.4
46.7
Myopia
0
7.4
46.7
Abnormality of refraction
1
42.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, receptor type R
VGNC:8507
452076
Macaque
protein tyrosine phosphatase, receptor type R
718582
Mouse
MGI:109559
19279
Rat
RGD:620780
94202
Dog
protein tyrosine phosphatase, receptor type R
VGNC:45197
481163
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, receptor type R
Macaque
protein tyrosine phosphatase, receptor type R
Mouse
Rat
Dog
protein tyrosine phosphatase, receptor type R
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15256-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (87)
1 – 10 of 87
MAPK14
Tchem
Family: Kinase
Novelty: 0.00045138
p_int: 0.999996041
p_ni: 0.000003959
Score: 0.857
Data Source: BioPlex,STRINGDB
MAPK1
Tchem
Family: Kinase
Novelty: 0.00061058
p_int: 0.944602628
p_ni: 0.055397372
Score: 0.993
Data Source: BioPlex,STRINGDB
MAPK3
Tchem
Family: Kinase
Novelty: 0.00012969
Score: 0.973
Data Source: STRINGDB
DUSP3
Tchem
Family: Enzyme
Novelty: 0.00518547
Score: 0.879
Data Source: STRINGDB
PTPN5
Tchem
Family: Enzyme
Novelty: 0.01499841
Score: 0.827
Data Source: STRINGDB
PTPN7
Tchem
Family: Enzyme
Novelty: 0.02742398
Score: 0.812
Data Source: STRINGDB
DUSP7
Tbio
Family: Enzyme
Novelty: 0.05499898
Score: 0.802
Data Source: STRINGDB
OCM2
Tdark
Novelty: 0.08257025
Score: 0.77
Data Source: STRINGDB
OCM
Tbio
Novelty: 0.00702069
Score: 0.769
Data Source: STRINGDB
INSRR
Tchem
Family: Kinase
Novelty: 0.00576355
Score: 0.762
Data Source: STRINGDB
Publication Statistics
PubMed Score  55.74

PubMed score by year
PubTator Score  20

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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