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Tbio
NONO
Non-POU domain-containing octamer-binding protein

Protein Summary
Description
DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRC ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276079
  • ENSP00000276079
  • ENSG00000147140
  • ENST00000373841
  • ENSP00000362947
  • ENST00000373856
  • ENSP00000362963
  • ENST00000535149
  • ENSP00000441364

Symbol
  • NRB54
  • P54
  • NMT55
  • NRB54
  • MRXS34
  • P54NRB
  • PPP1R114
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
disease perturbation
1
interacting protein
1
ligand (protein) perturbation
1
hub protein
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 529.52   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 485   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 529.52   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 485   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (25)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (193)
1 – 10 of 193
TET2
Tbio
Family: Enzyme
Novelty: 0.00219804
p_int: 0.99999647
p_ni: 0.000003454
p_wrong: 7.5e-8
Score: 0.335
Data Source: BioPlex,STRINGDB
PROSER1
Tdark
p_int: 0.999994998
p_ni: 6.04e-7
p_wrong: 0.000004398
Score: 0.39
Data Source: BioPlex,STRINGDB
SFPQ
Tbio
Novelty: 0.01546419
p_int: 0.999931729
p_ni: 0.000068271
Score: 0.999
Data Source: BioPlex,STRINGDB
GYG2
Tbio
Family: Enzyme
Novelty: 0.01017368
p_int: 0.99989458
p_ni: 0.000105293
p_wrong: 1.27e-7
Score: 0.177
Data Source: BioPlex,STRINGDB
PSPC1
Tbio
Novelty: 0.01437046
p_int: 0.998828269
p_ni: 0.001171731
Score: 0.995
Data Source: BioPlex,STRINGDB
SERPINB7
Tbio
Novelty: 0.01951612
p_int: 0.998408795
p_ni: 0.001591201
p_wrong: 3e-9
Score: 0.173
Data Source: BioPlex,STRINGDB
SERPINB8
Tbio
Novelty: 0.00412031
p_int: 0.994776172
p_ni: 0.005223828
Score: 0.179
Data Source: BioPlex,STRINGDB
SERPINA12
Tbio
Novelty: 0.00636095
p_int: 0.992497493
p_ni: 0.007502507
Data Source: BioPlex
ASAH1
Tchem
Family: Enzyme
Novelty: 0.00478738
p_int: 0.90328923
p_ni: 0.09671077
Data Source: BioPlex
CCDC22
Tbio
Novelty: 0.01857112
p_int: 0.895691937
p_ni: 0.104308063
Data Source: BioPlex
Publication Statistics
PubMed Score  529.52

PubMed score by year
PubTator Score  109.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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